Dao Duc Thien, Nguyen Hoang Sa, Le Quoc Thang, Nguyen Thanh Tam
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引用次数: 0
Abstract
A new cyclohexenone, 5S-(3,4-dihydroxyphenethyl)cyclohex-2-en-1-one (1), along with two new phenanthrones, (4aS,10aS)- 1,9,10,10a -tetrahydro-4a,6,7-trihydroxy-4(4aH)-phenanthrone (2) and (4aS,10aS)-4a-hydroxy-7-methoxy-1,9,10,10a-tetrahydro-4(4aH)-phenanthrone 6-O-β-D-glucopyranoside (3) were isolated from the whole plant of Elatostema tenuicaudatum. The structures were determined by spectroscopic methods including 1D, 2D NMR and HR-ESI-MS. The absolute configurations of compounds 1-3 were determined by their experimental and calculated ECD spectral data. The isolates were evaluated for inhibitory activity on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophage cells, and compound 2 showed the strongest activity with an IC50 value of 9.5 ± 1.2 μM.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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