The role of calcium serum level in clinical manifestation and progress of psoriasis vulgaris in a patient with Fahr's syndrome.

IF 1 Q2 DERMATOLOGY

Dermatology Reports Pub Date : 2026-09-01 Epub Date: 2025-10-28 DOI:10.4081/dr.2025.10614

Migena Vargu, Sabina Dedej, Petrit Vargu, Eriselda Kurushi, Anxhela Nisi, Samuele Vargu

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Abstract

Fahr's syndrome is a rare entity characterized by symmetrical and bilateral non-atherosclerotic intracerebral calcifications in the basal ganglia. This entity is usually asymptomatic or may present mainly with neuro-neuropsychiatric and dermatological manifestations. Secondary bilateral striopallidodentate calcinosis (BSPDC) presentations are associated with various diseases. We describe a case of psoriasis vulgaris associated with secondary BSPDC due to hypoparathyroidism. Laboratory tests revealed hypocalcemia, hyperphosphatemia, and a low parathormone serum level; on cerebral computed tomography (CT), bilateral basal ganglia calcification was observed. Correction of calcium deficiency restored the calcium-phosphate balance and led to an improvement in psoriatic lesions. Psoriasis vulgaris is a common condition that may be associated with disturbances in calcium metabolism. Dermatologists should be aware that investigating cases resistant to conventional therapies can uncover underlying systemic disorders that significantly affect patients' quality of life.

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血清钙水平在Fahr综合征寻常型银屑病临床表现及进展中的作用

Fahr综合征是一种罕见的以基底节区对称和双侧非动脉粥样硬化性脑内钙化为特征的疾病。这种疾病通常无症状或主要表现为神经-神经精神和皮肤病学表现。继发性双侧striopallidodentate calcinosis （BSPDC）与多种疾病有关。我们描述了一个寻常型银屑病与继发性BSPDC相关的病例，由于甲状旁腺功能低下。实验室检查显示低钙血症、高磷血症和低甲状旁激素血清水平；CT显示双侧基底节区钙化。纠正缺钙恢复钙-磷酸盐平衡，导致银屑病病变的改善。寻常型牛皮癣是一种常见的疾病，可能与钙代谢紊乱有关。皮肤科医生应该意识到，调查对传统疗法有耐药性的病例可以发现潜在的系统性疾病，这些疾病会显著影响患者的生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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