The characteristic of virulence and antibiotic resistance of metallo-carbapenemases-producing Klebsiella spp. in a tertiary hospital in China.

IF 1.2 4区医学 Q4 MICROBIOLOGY

New Microbiologica Pub Date : 2025-10-01

Ruixue Ma, Yu Jingying, Yinyun Lu, Yongchun Ruan, Jinnan Duan, Dan Wang, Guofeng Mao, Minghui Li, Yiqing Zhou

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Abstract

The emergence and global dissemination of carbapenem-resistant Klebsiella spp. have seriously threatened global public health. Few genomic analyses of ceftazidime-avibactam-resistant and carbapenem-resistant Klebsiella spp. (CAR-CRKS) have been performed to date. This was a retrospective study of 12 CAR - CRKS isolates from 99 Klebsiella spp. collected in a Chinese tertiary hospital between 2018 and 2020. K. pneumoniae (eight cases, 66.67%), K. variicola (two cases, 16.67%), and K. quasipneumoniae (two cases, 16.67%) were identified in these isolates. Most of these patients had underlying hepatobiliary diseases or a history of receiving interventional procedures, and were hospitalised recurrently. The isolates were sensitive to amikacin, tigecycline, and polymyxin. blaIMP-4 was detected in six isolates, whereas blaNDM-1, blaNDM-5 and blaNDM-9 were detected in three, two, and one isolates, respectively. Only one strain harboured the rmpA, and exhibited a hypermucinous phenotype. The aerobactin (iucABCD) and yersiniabactin genes were absent in most of the strains. The strains containing blaIMP-4 exhibited higher virulence. These findings are of great significance for understanding the characteristics of CAR - CRKS and developing treatment strategies.

本刊更多论文

中国某三级医院产金属碳青霉烯酶克雷伯氏菌的毒力及耐药性特点。

耐碳青霉烯克雷伯菌的出现和全球传播已严重威胁到全球公共卫生。迄今为止，对头孢他啶-阿维巴坦耐药和碳青霉烯耐药克雷伯氏菌（CAR-CRKS）的基因组分析很少。本研究是对2018年至2020年在中国某三级医院收集的99种克雷伯氏菌的12株CAR - CRKS分离株进行回顾性研究。检出肺炎克雷伯菌（8例，占66.67%）、天花克雷伯菌（2例，占16.67%）和准肺炎克雷伯菌（2例，占16.67%）。这些患者大多有潜在的肝胆疾病或接受介入性手术的历史，并且经常住院。分离株对阿米卡星、替加环素和多粘菌素敏感。blaIMP-4在6株分离株中检出，blaNDM-1、blaNDM-5和blaNDM-9分别在3株、2株和1株中检出。只有一个菌株携带rmpA，并表现出高粘液表型。在大多数菌株中不存在有氧肌动蛋白（iucABCD）和耶尔森肌动蛋白基因。含有blaIMP-4的菌株表现出较高的毒力。这些发现对于了解CAR - CRKS的特点和制定治疗策略具有重要意义。

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来源期刊

New Microbiologica 生物-微生物学

CiteScore

2.20

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： The publication, diffusion and furtherance of research and study on all aspects of basic and clinical Microbiology and related fields are the chief aims of the journal.