Memory Performance and Hippocampal Volumes in Healthy Weight Children at High- and Low-Familial Risk for Obesity

IF 2.5 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2025-10-26 DOI:10.1111/ijpo.70061

Melanie A. Dratva, Zoe L. Lanman, Amanda Bischoff-Grethe, Dawn M. Eichen, David R. Strong, Christina E. Wierenga, Kerri N. Boutelle

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引用次数: 0

Abstract

Background

Children with overweight or obesity (OW/OB), relative to healthy weight (HW), have lower cognitive performance and hippocampal volumes. Whether this extends to children with HW at familial risk for future OW/OB is unknown.

Objectives

To compare memory performance and hippocampal subfield volumes between HW children at high risk (HR) and low risk (LR) for OW/OB.

Methods

HW children (n = 95, aged 8–11), classified as HR (n = 43, both parents with OW/OB) or LR (n = 52, both parents with HW), underwent structural magnetic resonance imaging and memory testing (Verbal List Learning Test-Food-Child Version (VLLT-Food-C) and Child Memory Scale subtests: word pairs, dot locations). Linear models tested group differences in memory scores, hippocampal and subfield (CA1, CA3, dentate gyrus (DG), subiculum) volumes.

Results

Groups did not differ on demographics except body mass index (HR > LR, p = 0.003), despite all children being HW. LR children performed better on VLLT-Food-C short- ( $β$ = 0.34, p < 0.01) and long-delay cued recall ( $β$ = 0.21, p = 0.04) and word pairs delayed recall ( $β$ = 0.21, p = 0.04). Children with HR had smaller bilateral whole hippocampus, CA1, DG and right CA3 volumes (ps < 0.05); only the right DG remained significant ( $β$ = 0.15, p = 0.04) after intracranial volume adjustment.

Conclusions

Memory and hippocampal volume differences may reflect underlying familial risk of OW/OB in HW children.

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高、低家族性肥胖风险健康体重儿童的记忆表现和海马体体积

背景：与健康体重（HW）相比，超重或肥胖儿童（OW/OB）的认知能力和海马体积较低。这是否适用于有家族性OW/OB风险的HW患儿尚不清楚。目的：比较OW/OB高风险（HR）和低风险（LR） HW儿童的记忆表现和海马亚区体积。方法：HW儿童（n = 95，年龄8-11岁），分为HR组（n = 43，父母双方均患有OW/OB）和LR组（n = 52，父母双方均患有HW），采用结构磁共振成像和记忆测试（言语表学习测试-食物-儿童版（VLLT-Food-C）和儿童记忆量表子测试：单词对、点位置）。线性模型测试各组在记忆评分、海马和子区（CA1、CA3、齿状回（DG）、丘下）体积方面的差异。结果：各组在人口统计学上没有差异，除了身体质量指数（HR > LR, p = 0.003），尽管所有儿童都是高体重。LR儿童在VLLT-Food-C短记忆（β $$ \beta $$ = 0.34, p β $$ \beta $$ = 0.21, p = 0.04）和单词对延迟回忆（β $$ \beta $$ = 0.21, p = 0.04）上表现较好。颅内容积调整后，HR患儿双侧海马全区、CA1、DG、右侧CA3体积减小（ps β $$ \beta $$ = 0.15, p = 0.04）。结论：记忆和海马体积的差异可能反映了HW儿童OW/OB的潜在家族风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.