Synthesis and Characterization of Gelatin-Based Nanoparticles for Potential Drug Delivery in Neurodegenerative Disease Treatment

IF 1.2 4区化学 Q4 POLYMER SCIENCE

Polymer Science, Series A Pub Date : 2025-10-27 DOI:10.1134/S0965545X25600760

Oscar Ruiz-Galindo, Ana Castro-Ceseña, Mirian A. González Ayon, Angel Licea-Claverie, Arturo Zizumbo-López, Sergio A. Aguila

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Abstract

Gelatin-core/poly(ethyleneglycol)-shell structured nanoparticles were synthesized via soap-free emulsion polymerization, gelatin and poly(ethylene glycol) were modified with methacrylic anhydride into methacrylated gelatin (GelMA) and poly(ethyleneglycol) dimethacrylate (PEGDMA), characterized by different techniques and used as macro-comonomers. Nanoparticles were prepared using different macro-comonomer ratios which translated into different sizes as revealed by dynamic light scattering measurements. Nanoparticles were then loaded with clioquinol as model drug for Alzheimer’s treatment, and their drug release behavior was studied, finding that nanogels impart a controlled release directly correlated with the amount of PEGDMA in relation to GelMA in them. Nanoparticles were found to be biocompatible when tested by the MTT assay on human skin fibroblasts. These characteristics make the synthesized nanogels prime candidates for their potential use as drug carriers for neurodegenerative disease treatment.

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用于神经退行性疾病治疗的潜在药物递送的明胶纳米颗粒的合成和表征

采用无皂乳液聚合的方法合成了明胶核/聚乙二醇壳结构纳米颗粒，用甲基丙烯酸酐对明胶和聚乙二醇进行改性，制备了甲基丙烯酸明胶（GelMA）和聚乙二醇二甲基丙烯酸酯（PEGDMA），并采用不同的工艺对其进行了表征。采用不同的宏观单体比例制备了不同尺寸的纳米颗粒，并通过动态光散射测量得到了结果。然后将纳米颗粒装入clioquinol作为治疗阿尔茨海默病的模型药物，并对其药物释放行为进行了研究，发现纳米凝胶的药物释放与PEGDMA和GelMA的含量直接相关。在人皮肤成纤维细胞上进行MTT试验，发现纳米颗粒具有生物相容性。这些特性使合成的纳米凝胶成为神经退行性疾病治疗药物载体的潜在候选者。

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来源期刊

Polymer Science, Series A 化学-高分子科学

CiteScore

1.70

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Polymer Science, Series A is a journal published in collaboration with the Russian Academy of Sciences. Series A includes experimental and theoretical papers and reviews devoted to physicochemical studies of the structure and properties of polymers (6 issues a year). All journal series present original papers and reviews covering all fundamental aspects of macromolecular science. Contributions should be of marked novelty and interest for a broad readership. Articles may be written in English or Russian regardless of country and nationality of authors. All manuscripts are peer reviewed. Online submission via Internet to the Series A, B, and C is available at http://polymsci.ru.