Association between hypertension and kidney stones: a cross-sectional analysis from NHANES and Mendelian randomization.

IF 3 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Aging Male Pub Date : 2025-12-11 Epub Date: 2025-10-24 DOI:10.1080/13685538.2025.2571937

Shan He, Yi Wei Chen, Lian Ying Hu, Qin Kai Chen, Yu Wang, Si Yi Liu

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引用次数: 0

Abstract

Background: The association between hypertension and kidney stones remains inconsistent. This research investigated the relationship between hypertension and the risk and progression of kidney stones.

Methods: A cross-sectional analysis was performed using data from the National Health and Nutrition Examination Survey (NHANES). The association was assessed with a multivariable logistic regression model. Furthermore, a two-sample Mendelian randomization (MR) analysis was conducted to evaluate causality. Methods included inverse-variance weighted (IVW), weighted median, and sensitivity analyses. Summary-level data for kidney stones were obtained from the UK Biobank, and for hypertension from a genome-wide association study (GWAS)analysis.

Results: The NHANES analysis included 21,740 participants. After full adjustment, hypertension was significantly associated with a higher prevalence of kidney stones (odds ratio [OR] = 1.36, 95% confidence interval [CI]: 1.19-1.56, p < 0.001). In the MR analysis, the IVW method indicated a causal effect of hypertension on kidney stones (OR = 1.01, 95% CI: 1.00-1.01, p = 0.013), supported by the weighted median method (OR = 1.01, 95% CI: 1.00-1.02, p = 0.002). Sensitivity analyses revealed no significant heterogeneity or pleiotropy.

Conclusions: Our investigation revealed a heightened risk of kidney stones linked to hypertension, which necessitates validation through further large-scale prospective cohort studies.

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高血压和肾结石之间的关系：来自NHANES和孟德尔随机化的横断面分析。

背景：高血压和肾结石之间的关系仍然不一致。本研究探讨了高血压与肾结石风险和进展之间的关系。方法：采用全国健康与营养检查调查（NHANES）的数据进行横断面分析。用多变量logistic回归模型评估其相关性。此外，进行了双样本孟德尔随机化（MR）分析来评估因果关系。方法包括反方差加权（IVW）、加权中位数和敏感性分析。肾结石的汇总数据来自英国生物银行，高血压的汇总数据来自全基因组关联研究（GWAS）分析。结果：NHANES分析纳入了21,740名参与者。在完全调整后，高血压与肾结石的高患病率显著相关（优势比[OR] = 1.36, 95%可信区间[CI]: 1.19-1.56, pp = 0.013），加权中位数法支持这一结论（OR = 1.01, 95% CI: 1.00-1.02, p = 0.002）。敏感性分析显示没有显著的异质性或多效性。结论：我们的调查显示，肾结石与高血压相关的风险增加，这需要通过进一步的大规模前瞻性队列研究来验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Male 医学-泌尿学与肾脏学

CiteScore

6.40

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Aging Male , the official journal of the International Society for the Study of the Aging Male, is a multidisciplinary publication covering all aspects of male health throughout the aging process. The Journal is a well-recognized and respected resource for anyone interested in keeping up to date with developments in this field. It is published quarterly in one volume per year. The Journal publishes original peer-reviewed research papers as well as review papers and other appropriate educational material that provide researchers with an integrated perspective on this new, emerging specialty. Areas of interest include, but are not limited to: Diagnosis and treatment of late-onset hypogonadism Metabolic syndrome and related conditions Treatment of erectile dysfunction and related disorders Prostate cancer and benign prostate hyperplasia.