Irina Sergeevna Boksha, Olga Konstantinovna Savushkina, Tatyana Andreevna Prokhorova, Elena Borisovna Tereshkina, Liubov Vasilievna Androsova, Tatyana Petrovna Safarova, Olga Borisovna Yakovleva, Irina Nikolaevna Othman, Gulnur Shingojievna Burbaeva
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引用次数: 0
Abstract
Introduction: Heterogeneity of patients with late-life depression (LLD) makes it difficult to predict their responses to treatment.
Methods: Hundred patients with LLD were stratified into clusters based on ten blood biochemical and immunological parameters measured at baseline. The treatment responses and clinical characteristics of the patients in the resulting clusters were compared.
Results: The resulting 4 clusters of patients significantly differed in treatment responses and in a number of clinical traits.
Conclusion: The study confirms the link between the activities of enzymes involved in energy, glutamate metabolism, and antioxidant and immune systems in patients with LLD and their response to therapy as well as their certain clinical characteristics.
期刊介绍：
In view of the ever-increasing fraction of elderly people, understanding the mechanisms of aging and age-related diseases has become a matter of urgent necessity. ''Gerontology'', the oldest journal in the field, responds to this need by drawing topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality. The range of papers is classified into four sections. In the Clinical Section, the aetiology, pathogenesis, prevention and treatment of agerelated diseases are discussed from a gerontological rather than a geriatric viewpoint. The Experimental Section contains up-to-date contributions from basic gerontological research. Papers dealing with behavioural development and related topics are placed in the Behavioural Science Section. Basic aspects of regeneration in different experimental biological systems as well as in the context of medical applications are dealt with in a special section that also contains information on technological advances for the elderly. Providing a primary source of high-quality papers covering all aspects of aging in humans and animals, ''Gerontology'' serves as an ideal information tool for all readers interested in the topic of aging from a broad perspective.
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