Role of C-reactive protein in cervical intraepithelial neoplasia/cancer

IF 3.7 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2025-12-01 Epub Date: 2025-10-19 DOI:10.1016/j.prp.2025.156274

Adriana Pedreañez , Yenddy Carrero , Renata Vargas , Juan P.Hernández Fonseca , Jesús Mosquera

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引用次数: 0

Abstract

Cervical cancer is one of the most common malignancies in women. This pathology originates from the progression of cervical intraepithelial neoplasia (CIN), induced by high-risk human papillomavirus (HPV) infection. During CIN, an inflammatory process characterized by immune system activation and increased levels of C-reactive protein (CRP) occurs. This protein, generally an indicator of inflammatory processes, also has functions that can influence the pathogenesis of several diseases. This review summarizes the current published literature (searched on Pubmed, EMBASE and Web of Science) regarding the factors that affect pathogenesis of cervical intraepithelial neoplasia/cancer mediated by CRP searched up to 2025. This review highlights the events present in CIN/cancer where CRP may be involved. CRP may induce progression of CIN to cervical cancer through its action on its lectin-like receptor oxidized low-density lipoprotein receptor-1 (LOX-1) and influence events involving complement activation, immune system activation, apoptosis induction, oxidative stress, and modulation of HPV biology.

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c反应蛋白在宫颈上皮内瘤变/癌中的作用

子宫颈癌是女性最常见的恶性肿瘤之一。这种病理起源于宫颈上皮内瘤变（CIN）的进展，由高危人乳头瘤病毒（HPV）感染引起。在CIN期间，以免疫系统激活和c反应蛋白（CRP）水平升高为特征的炎症过程发生。这种蛋白质通常是炎症过程的指示器，也具有影响几种疾病发病机制的功能。本综述总结了目前已发表的文献（检索Pubmed、EMBASE和Web of Science），关于CRP介导的宫颈上皮内瘤变/癌发病机制的影响因素，检索至2025年。这篇综述强调了在CIN/癌症中CRP可能参与的事件。CRP可能通过其对凝集素样受体氧化低密度脂蛋白受体-1 （LOX-1）的作用诱导CIN进展为宫颈癌，并影响补体激活、免疫系统激活、细胞凋亡诱导、氧化应激和HPV生物学调节等事件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.