Results of transoral injection laryngoplasty in the apneic window

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY

Auris Nasus Larynx Pub Date : 2025-12-01 Epub Date: 2025-10-24 DOI:10.1016/j.anl.2025.10.009

Nurullah Türe , Serkan Telli , Onur Kibar

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引用次数: 0

Abstract

Objectives

The aim of this study was report the feasibility, safety profile, and within-patient voice outcomes of transoral injection laryngoplasty performed during a protocolized apneic window in unilateral vocal fold paralysis (UVFP).

Methods

This retrospective single-arm cohort study included patients who underwent transoral IL in the apneic window because of UVFP between February 2021 and March 2024. The following parameters were compared before and after the injection: GRBAS, maximum phonation time (MPT,seconds), Turkish Voice Handicap Index-10 (T-VHI-10), Turkish Voice-Related Quality of Life Questionnaire (T-V-RQOL), Turkish Eating Assessment Tool (T-EAT-10), and acoustic analysis parameters (F0, Jitter (%), Shimmer (%), CPPs, AVQI v03.01).

Results

Final analysis was made of 27 patients, comprising 19 (70.4 %) females and 8 (29.6 %) males, with a mean age of 58 years (range, 21–75 years). Following the apneic window IL technique, statistically significant decreases were determined in the GRBAS G-score (2.36 vs.0.28, p < 0.001), MPT (5.68 vs.13.56 secs, p < 0.001), T-VHI-10 (28 vs. 6, p < 0.001), and T-EAT-10 (14 vs. 4, p < 0.001). In the acoustic voice analysis, statistically significant decreases were observed in Jitter % (0.67 vs. 0.3, p < 0.001), Shimmer % (5.81 vs.1.6, p < 0.001) and AVQI v03.01 (5.9 vs. 2.8, p < 0.001).

Conclusion

Transoral IL in an apneic window is a feasible and safe tubeless option that yielded significant within-patient improvements across perceptual, aerodynamic, patient-reported, and acoustic domains under a predefined safety workflow. The technique preserves a wide, tube-free operative field and may be considered complementary in selected candidates. Comparative studies versus intubated IL are warranted to establish non-inferiority or superiority.

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呼吸暂停期经口注射喉成形术的效果

本研究的目的是报告在单侧声带麻痹（UVFP）的协议性呼吸暂停窗口期间进行经口注射喉部成形术的可行性、安全性和患者内部语音结果。方法本回顾性单臂队列研究纳入了2021年2月至2024年3月期间因UVFP而在呼吸暂停窗口期接受经口IL治疗的患者。比较注射前后的以下参数：GRBAS、最大发声时间（MPT，秒）、土耳其语语音障碍指数-10 （T-VHI-10）、土耳其语语音相关生活质量问卷（T-V-RQOL）、土耳其语进食评估工具（T-EAT-10）和声学分析参数（F0、抖动（%）、闪烁（%）、CPPs、AVQI v03.01）。结果最终分析27例患者，女性19例（70.4%），男性8例（29.6%），平均年龄58岁（21 ~ 75岁）。采用呼吸暂停窗IL技术后，GRBAS g评分（2.36 vs.0.28, p < 0.001）、MPT （5.68 vs.13.56秒，p < 0.001）、T-VHI-10 （28 vs. 6, p < 0.001）和T-EAT-10 （14 vs. 4, p < 0.001）均有统计学显著降低。在声学语音分析中，抖动% （0.67 vs. 0.3, p < 0.001）、闪烁% （5.81 vs.1.6, p < 0.001）和AVQI v03.01 （5.9 vs. 2.8, p < 0.001）均有统计学显著降低。结论：在呼吸暂停窗口中经口IL是一种可行且安全的无管选择，在预定义的安全工作流程下，在感知、空气动力学、患者报告和声学领域取得了显着的患者内改善。该技术保留了一个宽的，无管的手术领域，并且可以被认为是选定候选者的补充。与插管IL的比较研究有理由建立非劣效性或优越性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Auris Nasus Larynx 医学-耳鼻喉科学

CiteScore

3.40

自引率

5.90%

发文量

169

审稿时长

30 days

期刊介绍： The international journal Auris Nasus Larynx provides the opportunity for rapid, carefully reviewed publications concerning the fundamental and clinical aspects of otorhinolaryngology and related fields. This includes otology, neurotology, bronchoesophagology, laryngology, rhinology, allergology, head and neck medicine and oncologic surgery, maxillofacial and plastic surgery, audiology, speech science. Original papers, short communications and original case reports can be submitted. Reviews on recent developments are invited regularly and Letters to the Editor commenting on papers or any aspect of Auris Nasus Larynx are welcomed. Founded in 1973 and previously published by the Society for Promotion of International Otorhinolaryngology, the journal is now the official English-language journal of the Oto-Rhino-Laryngological Society of Japan, Inc. The aim of its new international Editorial Board is to make Auris Nasus Larynx an international forum for high quality research and clinical sciences.