RBC deformability and clinical relevance in transfusion recipients

IF 1.2 4区医学 Q4 HEMATOLOGY

Transfusion and Apheresis Science Pub Date : 2025-12-01 Epub Date: 2025-10-19 DOI:10.1016/j.transci.2025.104278

Mahsa Yazdanbakhsh , Celina Phan , Pratham Patel , Ethan Simpson , Kaitlyn Wingnean , Jason P. Acker

{"title":"RBC deformability and clinical relevance in transfusion recipients","authors":"Mahsa Yazdanbakhsh , Celina Phan , Pratham Patel , Ethan Simpson , Kaitlyn Wingnean , Jason P. Acker","doi":"10.1016/j.transci.2025.104278","DOIUrl":null,"url":null,"abstract":"<div><div>Red blood cell (RBC) deformability—the ability of RBCs to change shape—is crucial for their passage through microvessels and effective oxygen delivery. Deformability depends on the cell’s surface area-to-volume ratio, internal viscosity, and membrane elasticity. Deformability is assessed using single-cell methods like micropipette aspiration and bulk flow techniques such as ektacytometry. RBC deformability decreases during cold storage due to biochemical and structural changes known as storage lesions. Additional processes like cryopreservation and irradiation further impair the deformability of stored RBCs. Donor factors, including age, sex, lifestyle, and health, also influence RBC mechanical properties, affecting transfusion outcomes. Clinically, transfusing RBCs with reduced deformability is linked to impaired microvascular flow, decreased oxygen delivery, and faster clearance from the circulation, especially in patients with chronic or inflammatory conditions. Despite its importance, deformability testing is not yet standard in transfusion practice. New technologies offer potential for routine deformability assessment which could improve transfusion outcomes by optimizing RBC quality and matching units to patient needs.</div></div>","PeriodicalId":49422,"journal":{"name":"Transfusion and Apheresis Science","volume":"64 6","pages":"Article 104278"},"PeriodicalIF":1.2000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transfusion and Apheresis Science","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1473050225002216","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/10/19 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"HEMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Red blood cell (RBC) deformability—the ability of RBCs to change shape—is crucial for their passage through microvessels and effective oxygen delivery. Deformability depends on the cell’s surface area-to-volume ratio, internal viscosity, and membrane elasticity. Deformability is assessed using single-cell methods like micropipette aspiration and bulk flow techniques such as ektacytometry. RBC deformability decreases during cold storage due to biochemical and structural changes known as storage lesions. Additional processes like cryopreservation and irradiation further impair the deformability of stored RBCs. Donor factors, including age, sex, lifestyle, and health, also influence RBC mechanical properties, affecting transfusion outcomes. Clinically, transfusing RBCs with reduced deformability is linked to impaired microvascular flow, decreased oxygen delivery, and faster clearance from the circulation, especially in patients with chronic or inflammatory conditions. Despite its importance, deformability testing is not yet standard in transfusion practice. New technologies offer potential for routine deformability assessment which could improve transfusion outcomes by optimizing RBC quality and matching units to patient needs.

查看原文本刊更多论文

输血受者红细胞变形性及其临床意义

红细胞（RBC）的变形能力——红细胞改变形状的能力——对于它们通过微血管和有效的氧气输送至关重要。可变形性取决于细胞的表面积体积比、内部粘度和膜弹性。可变形性评估使用单细胞方法，如微移液管抽吸和体积流技术，如ekacytometry。红细胞的变形能力在冷藏过程中由于生化和结构的变化而降低。冷冻保存和辐照等附加过程进一步损害了储存红细胞的可变形性。供体因素，包括年龄、性别、生活方式和健康状况，也会影响红细胞的力学特性，影响输血结果。临床上，输注可变形性降低的红细胞与微血管血流受损、氧输送减少和血液循环清除速度加快有关，特别是在慢性或炎症患者中。尽管它很重要，但在输血实践中，变形性检测尚未成为标准。新技术提供了常规可变形性评估的潜力，可以通过优化RBC质量和匹配患者需要的单位来改善输血结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Transfusion and Apheresis Science 医学-血液学

CiteScore

3.60

自引率

5.30%

发文量

181

审稿时长

42 days

期刊介绍： Transfusion and Apheresis Science brings comprehensive and up-to-date information to physicians and health care professionals involved in the rapidly changing fields of transfusion medicine, hemostasis and apheresis. The journal presents original articles relating to scientific and clinical studies in the areas of immunohematology, transfusion practice, bleeding and thrombotic disorders and both therapeutic and donor apheresis including hematopoietic stem cells. Topics covered include the collection and processing of blood, compatibility testing and guidelines for the use of blood products, as well as screening for and transmission of blood-borne diseases. All areas of apheresis - therapeutic and collection - are also addressed. We would like to specifically encourage allied health professionals in this area to submit manuscripts that relate to improved patient and donor care, technical aspects and educational issues. Transfusion and Apheresis Science features a "Theme" section which includes, in each issue, a group of papers designed to review a specific topic of current importance in transfusion and hemostasis for the discussion of topical issues specific to apheresis and focuses on the operators'' viewpoint. Another section is "What''s Happening" which provides informal reporting of activities in the field. In addition, brief case reports and Letters to the Editor, as well as reviews of meetings and events of general interest, and a listing of recent patents make the journal a complete source of information for practitioners of transfusion, hemostasis and apheresis science. Immediate dissemination of important information is ensured by the commitment of Transfusion and Apheresis Science to rapid publication of both symposia and submitted papers.