Achievements and challenges of targeted drug delivery to a human respiratory tract: Bridging traditional and novel approaches to modelling and clinical needs

IF 2.9 3区环境科学与生态学 Q2 ENGINEERING, CHEMICAL

Journal of Aerosol Science Pub Date : 2026-01-01 Epub Date: 2025-10-15 DOI:10.1016/j.jaerosci.2025.106706

R.M. Ainetdinov , D.V. Antonov , S.N. Avdeev , B.-Y. Cao , S.A. Kerimbekova , N. Liu , Z.M. Merzhoeva , O.V. Nagatkina , L.Yu. Nikitina , O. Rybdylova , S.S. Sazhin , E.S. Sokolova , P.A. Strizhak , O.A. Suvorova

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Abstract

Achievements and challenges of targeted drug delivery to a human respiratory tract are summarised. These include an analysis of the means of targeted drug delivery, which were used in the past, are currently available, and are expected to be used in the future. Particular attention is paid to the prioritisation of drugs and means of their targeted delivery. This analysis is followed by a description of pharmacological, experimental and theoretical advances in targeted drug delivery to a human respiratory tract. A description of the theoretical advances focuses on the theoretical tools currently available and used for the analysis of drug delivery processes, and those which were developed for different applications, mainly in engineering, but could potentially be applicable to the analysis of drug delivery processes in human airways. The latter include the full Lagrangian approach, and recently developed models of mono- and multi-component, and spherical and non-spherical droplet/aerosol heating and evaporation. Particular attention is given to molecular dynamics approaches to modelling aerosols, including their dynamics, heating and evaporation.

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人类呼吸道靶向给药的成就和挑战：连接传统和新型方法来建模和临床需求

总结了人类呼吸道靶向给药的成就和挑战。其中包括对过去使用的、目前可用的以及预计将来会使用的靶向给药手段的分析。特别注意药物的优先次序和有针对性地提供药物的手段。这一分析是随后的药理学，实验和理论进展的描述，在靶向药物输送到人类呼吸道。对理论进展的描述侧重于目前可用的和用于分析药物传递过程的理论工具，以及那些为不同应用而开发的理论工具，主要是在工程中，但可能适用于分析人体气道中的药物传递过程。后者包括完整的拉格朗日方法，以及最近开发的单组分和多组分模型，以及球形和非球形液滴/气溶胶加热和蒸发模型。特别注意分子动力学方法模拟气溶胶，包括其动力学，加热和蒸发。

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来源期刊

Journal of Aerosol Science 环境科学-工程：化工

CiteScore

8.80

自引率

8.90%

发文量

127

审稿时长

35 days

期刊介绍： Founded in 1970, the Journal of Aerosol Science considers itself the prime vehicle for the publication of original work as well as reviews related to fundamental and applied aerosol research, as well as aerosol instrumentation. Its content is directed at scientists working in engineering disciplines, as well as physics, chemistry, and environmental sciences. The editors welcome submissions of papers describing recent experimental, numerical, and theoretical research related to the following topics: 1. Fundamental Aerosol Science. 2. Applied Aerosol Science. 3. Instrumentation & Measurement Methods.