T follicular helper cell development during malaria

IF 5.6 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2025-12-01 Epub Date: 2025-10-23 DOI:10.1016/j.coi.2025.102682

Regina M Antonetti , Manan Shah , Noah S Butler

引用次数: 0

Abstract

Malaria is a life-threatening disease affecting more than 200 million people worldwide. CD4 T helper 1 (Th1) and T follicular helper (Tfh) cells are critical for stimulating phagocyte activation and humoral immunity, yet sterilizing, protective immune memory responses rarely develop. Malaria induces unique physiologic changes in the infected host that may give rise to nonconventional Tfh subsets and inefficient memory responses. While our understanding of the differentiation of conventional Tfh cells induced by Plasmodium infection is growing, how and whether malaria-associated environmental cues induce Tfh populations exhibiting mixed phenotype and function are not well defined. Moreover, little is known about the development and function of Tfh memory cells during malaria. In this review, we discuss the phenotype and known functions of Tfh subsets and memory development induced during malaria and highlight key priority knowledge gaps that remain to be addressed.

查看原文本刊更多论文

疟疾期间T滤泡辅助细胞的发育

疟疾是一种威胁生命的疾病，影响着全世界2亿多人。CD4 T辅助性1 （Th1）和T滤泡辅助性（Tfh）细胞在刺激吞噬细胞激活和体液免疫中起关键作用，但很少发生无菌性、保护性免疫记忆反应。疟疾在受感染宿主中引起独特的生理变化，可能导致非常规的Tfh亚群和低效的记忆反应。虽然我们对疟原虫感染诱导的传统Tfh细胞分化的了解越来越多，但疟疾相关的环境线索如何以及是否诱导Tfh群体表现出混合表型和功能还没有很好的定义。此外，人们对疟疾期间Tfh记忆细胞的发育和功能知之甚少。在这篇综述中，我们讨论了疟疾期间Tfh亚群的表型和已知功能以及记忆发育，并强调了仍有待解决的关键优先知识空白。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.