Designed dietary fibers: engineering carbohydrate structure for precision modulation of the human gut microbiome

IF 7.8 2区工程技术 Q1 BIOCHEMICAL RESEARCH METHODS

Current opinion in biotechnology Pub Date : 2025-12-01 Epub Date: 2025-10-23 DOI:10.1016/j.copbio.2025.103371

Marcelo Iñaki Guerrero Montalván , Mariana Guzmán Sánchez , Victoria Gutierrez , Yunus E Tunçil , Stephen R Lindemann

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Abstract

The human colonic microbiota exerts a profound influence on health, mediated by highly specific relationships among dietary fiber structures and microbial degraders. Systematic control of fiber structure offers opportunities to engineer microbiota-targeted interventions with increasing precision. Here, we examine the evolution of designed dietary fibers — biotechnologically produced oligosaccharides or polysaccharides synthesized de novo or naturally occurring polysaccharides intentionally modified post-extraction for their fine physical or chemical structures to influence gut microbiome. We propose a hierarchical framework to classify these fibers based on the degree of fine structure control, highlight current strategies for carbohydrate modification approaches, and discuss emerging directions for the field. Despite recent advances, much potential remains unrealized for the rational, reproducible design of microbiome-targeted fibers.

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设计膳食纤维：工程碳水化合物结构，精确调节人类肠道微生物群

人类结肠微生物群通过膳食纤维结构和微生物降解物之间的高度特定关系对健康产生深远影响。纤维结构的系统控制提供了以越来越精确的方式设计针对微生物群的干预的机会。在这里，我们研究了设计膳食纤维的演变-生物技术生产的低聚糖或重新合成的多糖或天然存在的多糖有意修改提取后的精细物理或化学结构，以影响肠道微生物群。我们提出了一个基于精细结构控制程度的分层框架来对这些纤维进行分类，重点介绍了碳水化合物改性方法的当前策略，并讨论了该领域的新兴方向。尽管最近取得了一些进展，但合理的、可重复的微生物群靶向纤维设计仍有很大的潜力有待实现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in biotechnology 工程技术-生化研究方法

CiteScore

16.20

自引率

2.60%

发文量

226

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Biotechnology (COBIOT) is renowned for publishing authoritative, comprehensive, and systematic reviews. By offering clear and readable syntheses of current advances in biotechnology, COBIOT assists specialists in staying updated on the latest developments in the field. Expert authors annotate the most noteworthy papers from the vast array of information available today, providing readers with valuable insights and saving them time. As part of the Current Opinion and Research (CO+RE) suite of journals, COBIOT is accompanied by the open-access primary research journal, Current Research in Biotechnology (CRBIOT). Leveraging the editorial excellence, high impact, and global reach of the Current Opinion legacy, CO+RE journals ensure they are widely read resources integral to scientists' workflows. COBIOT is organized into themed sections, each reviewed once a year. These themes cover various areas of biotechnology, including analytical biotechnology, plant biotechnology, food biotechnology, energy biotechnology, environmental biotechnology, systems biology, nanobiotechnology, tissue, cell, and pathway engineering, chemical biotechnology, and pharmaceutical biotechnology.