Cognitive factor structure of the NACC UDS-3 neuropsychological battery across ethno-racial, linguistic, and cognitive status groups.

IF 2.6 3区心理学 Q2 CLINICAL NEUROLOGY

Clinical Neuropsychologist Pub Date : 2026-08-01 Epub Date: 2025-10-24 DOI:10.1080/13854046.2025.2576154

Emily F Matusz, Jacob Fiala, Andrew M Kiselica, Mónica Rosselli, Melissa J Armstrong, Allison A Holgerson, Shellie-Anne Levy, Franchesca Arias, Idaly Vélez-Uribe, Ranjan Duara, Rosie E Curiel Cid, David A Loewenstein, Glenn E Smith, Michael Marsiske, Breton M Asken

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Abstract

Objective: There are diagnostic disparities in dementia across ethno-racial communities. The potential contribution of measurement bias in cognitive assessments was investigated by examining the factor structure and measurement invariance of the Uniform Data Set neuropsychological battery (UDS3-NB) across ethno-racial groups as well as Spanish and English speakers along a cognitive continuum. Methods: Data were from the National Alzheimer's Coordinating Center (NACC) and the 1Florida Alzheimer's Disease Research Center (1FLADRC). Confirmatory factor analyses were conducted in NACC (n = 29,462; M age = 71.0, SD = 10.4; 58.5% female, M education = 15.8, SD = 3.0; 68.6% non-Hispanic White, 5.3% -primary Spanish speaking) to determine the UDS3-NB factor structure. Measurement invariance was tested in NACC and separately within 1FLADRC (n = 829; M age = 69.9, SD = 8.5; 56.5% female; M education = 14.6, SD = 3.5 years; 33.3% non-Hispanic White, 33.8% primary Spanish speaking), across ethno-racial (non-Hispanic White, Hispanic White, Black/African American), primary language (English, Spanish), and cognitive status (cognitively normal, mild cognitive impairment, dementia). Invariance was assessed at configural, metric, scalar, and strict levels. Results: A 4-factor model (memory, processing speed/executive functioning, language, attention) demonstrated acceptable to good fit in NACC (CFI = 0.97, TLI = 0.96, RMSEA = 0.07, SRMR = 0.03) and 1FLADRC (CFI = 0.97, TLI = 0.96, RMSEA = 0.05, SRMR = 0.04). Standardized factor loadings ranged from 0.43-0.87. Metric invariance was supported across all contrasts in both cohorts. Higher levels of invariance were cohort-dependent: CN vs. MCI achieved strict invariance in both cohorts, whereas non-Hispanic White vs. Hispanic White and English vs. Spanish only achieved strict invariance in NACC. Conclusions: The UDS3-NB demonstrates structural validity and metric equivalence across ethno-racial, linguistic, and cognitive status groups.

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NACC - ads -3神经心理电池在不同种族、语言和认知地位群体中的认知因素结构

目的：不同种族社区的痴呆诊断存在差异。通过检查统一数据集神经心理电池（UDS3-NB）的因素结构和测量不变性，研究了认知评估中测量偏差的潜在贡献。方法：数据来自国家阿尔茨海默病协调中心（NACC）和佛罗里达州阿尔茨海默病研究中心（fladrc）。对NACC患者进行验证性因素分析（n = 29,462； M年龄= 71.0,SD = 10.4； 58.5%为女性；M学历= 15.8,SD = 3.0； 68.6%为非西班牙裔白人，5.3%为主要西班牙语使用者），以确定UDS3-NB因素结构。在NACC和1FLADRC中分别进行测量不变性检验（n = 829； M年龄= 69.9,SD = 8.5； 56.5%女性；M受教育程度= 14.6,SD = 3.5年；33.3%非西班牙裔白人，33.8%主要讲西班牙语），跨民族-种族（非西班牙裔白人，西班牙裔白人，黑人/非裔美国人），主要语言（英语，西班牙语）和认知状态（认知正常，轻度认知障碍，痴呆）。在配置、度量、标量和严格级别上评估不变性。结果：4因素模型（记忆、处理速度/执行功能、语言、注意力）对NACC （CFI = 0.97, TLI = 0.96, RMSEA = 0.07, SRMR = 0.03）和1FLADRC （CFI = 0.97, TLI = 0.96, RMSEA = 0.05, SRMR = 0.04）具有较好的拟合效果。标准化因子负荷范围为0.43-0.87。两个队列的所有对比均支持度量不变性。较高水平的不变性依赖于队列：CN与MCI在两个队列中都实现了严格的不变性，而非西班牙裔白人与西班牙裔白人以及英语与西班牙语仅在NACC中实现了严格的不变性。结论：UDS3-NB在民族、种族、语言和认知地位群体中具有结构效度和度量等效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neuropsychologist 医学-临床神经学

CiteScore

8.40

自引率

12.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The Clinical Neuropsychologist (TCN) serves as the premier forum for (1) state-of-the-art clinically-relevant scientific research, (2) in-depth professional discussions of matters germane to evidence-based practice, and (3) clinical case studies in neuropsychology. Of particular interest are papers that can make definitive statements about a given topic (thereby having implications for the standards of clinical practice) and those with the potential to expand today’s clinical frontiers. Research on all age groups, and on both clinical and normal populations, is considered.