Evaluating cognitive performance using cognitive performance using the National Institutes of Health Toolbox Cognitive Battery in children with traumatic brain injury.

IF 3 4区心理学 Q2 CLINICAL NEUROLOGY

Journal of the International Neuropsychological Society Pub Date : 2025-06-01 Epub Date: 2025-10-24 DOI:10.1017/S135561772510146X

Bailey Petersen, Ngoc-Thanh N Vo, Nivinthiga Anton, Keith Owen Yeates, Amery Treble-Barna

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引用次数: 0

Abstract

Objective: We examined cognitive performance in children with complicated mild-severe traumatic brain injury (TBI) versus orthopedic injury (OI) using the National Institutes of Health Toolbox Cognitive Battery (NIH TB-CB).

Method: We recruited children ages 3-18, hospitalized with complicated mild-severe TBI (n = 231) or orthopedic injury (OI, n = 146). Cognition was assessed using the NIH TB-CB at six and twelve months post-injury. We used linear mixed models to assess associations of injury group (TBI versus OI), timepoint (six versus twelve months), and the interaction of injury group and timepoint with NIH TB-CB Total Cognition, Fluid Cognition, and Crystallized Cognition composites, adjusted for sex and socioeconomic status (SES), with Bonferroni correction. We evaluated differences in cognition stratified by injury severity (complicated mild-moderate TBI vs severe TBI) using ANCOVA, adjusting for sex and SES.

Results: Neither injury group nor the interaction of group and timepoint were associated with Total (group: p = 0.50; timepoint*group: p = 0.185), Fluid (group: p = 0.297; timepoint*group: p = 0.842), or Crystallized Cognition (group: p = 0.039; timepoint*group: p = 0.017). However, children with severe TBI performed significantly worse on Fluid and Total Cognition than children with complicated mild-moderate TBI at six months (Fluid: p = 0.004, partial η² = 0.06, moderate effect, Total: p = 0.012 partial η² = 0.03, small-moderate effect) and twelve months post-injury (Fluid: p < 0.001, partial η² = 0.11, moderate-large effect, Total: p = 0.002, partial η² = 0.06, moderate effect).

Conclusions: The NIH TB-CB detects worse cognitive functioning in children with severe TBI six-twelve months post-injury, largely driven by differences in Fluid Cognition. Our findings suggest the NIH TB-CB may be suitable for monitoring cognition in children with TBI.

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使用美国国立卫生研究院工具箱认知电池评估创伤性脑损伤儿童的认知表现。

目的：我们使用美国国立卫生研究院工具箱认知电池（NIH TB-CB）检查复杂的轻重度创伤性脑损伤（TBI）与骨科损伤（OI）儿童的认知表现。方法：我们招募了年龄在3-18岁的儿童，这些儿童患有合并的中重度TBI （n = 231）或骨科损伤（n = 146）。在损伤后6个月和12个月使用NIH TB-CB评估认知。我们使用线性混合模型来评估损伤组（TBI vs OI）、时间点（6个月vs 12个月）的相关性，以及损伤组和时间点与NIH TB-CB总认知、流体认知和结晶认知复合材料的相互作用，调整性别和社会经济地位（SES），并进行Bonferroni校正。我们使用ANCOVA评估按损伤严重程度（复杂的轻度-中度TBI与严重TBI）分层的认知差异，调整性别和社会地位。结果：损伤组与Total（组：p = 0.50，时间点*组：p = 0.185）、Fluid（组：p = 0.297，时间点*组：p = 0.842）、晶态认知（组：p = 0.039，时间点*组：p = 0.017）均无相关性。然而，在损伤后6个月（Fluid: p = 0.004，偏η2 = 0.06，中等影响，Total: p = 0.012，偏η2 = 0.03，小-中等影响）和12个月（Fluid: p < 0.001，偏η2 = 0.11，中-大影响，Total: p = 0.002，偏η2 = 0.06，中等影响），重度TBI患儿的Fluid和Total cognitive表现明显差于合并轻中度TBI患儿。结论：NIH TB-CB检测到严重TBI儿童损伤后6 - 12个月认知功能恶化，主要是由流体认知差异引起的。我们的研究结果表明，NIH TB-CB可能适用于监测TBI儿童的认知。

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来源期刊

Journal of the International Neuropsychological Society 医学-精神病学

CiteScore

5.40

自引率

3.80%

发文量

185

审稿时长

4-8 weeks

期刊介绍： The Journal of the International Neuropsychological Society is the official journal of the International Neuropsychological Society, an organization of over 4,500 international members from a variety of disciplines. The Journal of the International Neuropsychological Society welcomes original, creative, high quality research papers covering all areas of neuropsychology. The focus of articles may be primarily experimental, applied, or clinical. Contributions will broadly reflect the interest of all areas of neuropsychology, including but not limited to: development of cognitive processes, brain-behavior relationships, adult and pediatric neuropsychology, neurobehavioral syndromes (such as aphasia or apraxia), and the interfaces of neuropsychology with related areas such as behavioral neurology, neuropsychiatry, genetics, and cognitive neuroscience. Papers that utilize behavioral, neuroimaging, and electrophysiological measures are appropriate. To assure maximum flexibility and to promote diverse mechanisms of scholarly communication, the following formats are available in addition to a Regular Research Article: Brief Communication is a shorter research article; Rapid Communication is intended for "fast breaking" new work that does not yet justify a full length article and is placed on a fast review track; Case Report is a theoretically important and unique case study; Critical Review and Short Review are thoughtful considerations of topics of importance to neuropsychology and include meta-analyses; Dialogue provides a forum for publishing two distinct positions on controversial issues in a point-counterpoint format; Special Issue and Special Section consist of several articles linked thematically; Letter to the Editor responds to recent articles published in the Journal of the International Neuropsychological Society; and Book Review, which is considered but is no longer solicited.