Xiaoying Zhang, Jue Wang, Na Wang, Yang Yang, Jinhuan Xu, Xiaojian Zhu, Gaoxiang Wang, Di Wang, Fankai Meng, Yi Xiao, Miao Zheng, Li Meng, Chunrui Li, Jia Wei, Yang Cao, Yicheng Zhang
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引用次数: 0
Abstract
We conducted a comparative analysis of the long-term efficacy and safety of two single-arm trials for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL): CD19/CD22-directed chimeric antigen receptor (CAR19/22) T-cell cocktail therapy alone or combined with autologous stem cell transplantation (ASCT). The study included 124 patients not in remission after bridging therapy. Cytopenia (36.92% vs. 52.54%) and infection (29.68% vs. 28.81%) were the predominant late grade ≥3 adverse events. CAR19/22 T-cell cocktail therapy combined with ASCT achieved a higher overall response rate (best overall response: 78.46% vs. 93.22%, P = 0.023) and superior progression-free survival (median, 5.68 months vs. not reached, P < 0.001) and overall survival (median, 27.61 months vs. not reached, P < 0.001) than CAR19/22 T-cell cocktail therapy alone. Independent predictors of longer progression-free survival and overall survival included achieving a complete response at 3 months and receiving combination therapy. The associations remained statistically significant after adjustment in sensitivity analyses incorporating propensity score matching and inverse probability of treatment weighting.
Significance: CAR19/22 T-cell therapy combined with ASCT significantly improves response and survival in R/R DLBCL, including high-risk patients. This approach seems to enhance the efficacy-safety balance and offers a clinically actionable strategy to optimize CAR T-cell combination therapies.
我们对治疗复发/难治性弥漫性大B细胞淋巴瘤（r/r DLBCL）的两项单臂试验的长期疗效和安全性进行了比较分析：CD19/CD22嵌合抗原受体（CAR19/22） t细胞鸡尾酒疗法（试验a）或联合自体干细胞移植（试验B）。该研究包括124例桥接治疗后未缓解的患者。细胞减少（36.92% vs.52.54%）和感染（29.68% vs. 28.81%）是晚期≥3级不良事件的主要原因。试验B获得了更高的总缓解率（最佳总缓解：93.22% vs. 78.46%， P=0.023）和更优的无进展生存期（PFS）（中位，5.68个月vs.未达到，P=0.023）
期刊介绍：
The journal Blood Cancer Discovery publishes high-quality Research Articles and Briefs that focus on major advances in basic, translational, and clinical research of leukemia, lymphoma, myeloma, and associated diseases. The topics covered include molecular and cellular features of pathogenesis, therapy response and relapse, transcriptional circuits, stem cells, differentiation, microenvironment, metabolism, immunity, mutagenesis, and clonal evolution. These subjects are investigated in both animal disease models and high-dimensional clinical data landscapes.
The journal also welcomes submissions on new pharmacological, biological, and living cell therapies, as well as new diagnostic tools. They are interested in prognostic, diagnostic, and pharmacodynamic biomarkers, and computational and machine learning approaches to personalized medicine. The scope of submissions ranges from preclinical proof of concept to clinical trials and real-world evidence.
Blood Cancer Discovery serves as a forum for diverse ideas that shape future research directions in hematooncology. In addition to Research Articles and Briefs, the journal also publishes Reviews, Perspectives, and Commentaries on topics of broad interest in the field.
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