Heritability Estimates from Twin Studies: The Efficiency of the MZA Design.

IF 1.3 4区医学 Q4 GENETICS & HEREDITY

Twin Research and Human Genetics Pub Date : 2025-10-24 DOI:10.1017/thg.2025.10022

David T Lykken, Seymour Geisser, Auke Tellegen

引用次数: 0

Abstract

The most accurate confidence intervals for estimates of heritability are based on Fisher's Z-transformation. Using these methods, Loehlin and Nichol's (1976) analysis is confirmed, viz., that it is pointless to estimate heritabilities from the classical twin method unless one is prepared to recruit upwards of 800 twin pairs for study. Even then the assumptions of that method are so improbable as to leave reasonable doubt about the true value of H. Estimates of H from the correlation of monozygotic twins reared apart (MZA twins), on the other hand, is remarkably more stable than that obtained by comparing MZ with DZ correlations. Moreover, estimates of H based on the MZA design rest upon more reasonable (and often testable) assumptions.

查看原文本刊更多论文

双胞胎研究的遗传力估计：MZA设计的效率。

估计遗传率最准确的置信区间是基于费雪的z变换。使用这些方法，Loehlin和Nichol（1976）的分析得到了证实，即，除非准备招募800对以上的双胞胎进行研究，否则用经典的双胞胎方法来估计遗传能力是毫无意义的。即使这样，该方法的假设也是如此不可能，以至于对H的真实值留下了合理的怀疑。另一方面，从分开抚养的同卵双胞胎（MZA双胞胎）的相关性中估计的H比通过比较MZ和DZ相关性获得的H要稳定得多。此外，基于MZA设计的H估计依赖于更合理的（通常是可测试的）假设。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Twin Research and Human Genetics 医学-妇产科学

CiteScore

1.50

自引率

11.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Twin Research and Human Genetics is the official journal of the International Society for Twin Studies. Twin Research and Human Genetics covers all areas of human genetics with an emphasis on twin studies, genetic epidemiology, psychiatric and behavioral genetics, and research on multiple births in the fields of epidemiology, genetics, endocrinology, fetal pathology, obstetrics and pediatrics. Through Twin Research and Human Genetics the society aims to publish the latest research developments in twin studies throughout the world.