{"title":"From prediction to understanding: Will AI foundation models transform brain science?","authors":"Thomas Serre, Ellie Pavlick","doi":"10.1016/j.neuron.2025.09.039","DOIUrl":null,"url":null,"abstract":"<p><p>Deep-learning approaches using massive data have transformed AI and are reshaping science. We ask when AI foundation models will transform neuroscience, outlining critical success conditions and a shift from prediction to explanation-linking computations to mechanisms of neural activity and cognition.</p>","PeriodicalId":19313,"journal":{"name":"Neuron","volume":" ","pages":""},"PeriodicalIF":15.0000,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuron","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.neuron.2025.09.039","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Deep-learning approaches using massive data have transformed AI and are reshaping science. We ask when AI foundation models will transform neuroscience, outlining critical success conditions and a shift from prediction to explanation-linking computations to mechanisms of neural activity and cognition.
期刊介绍:
Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.