The molecular mechanism of traditional Chinese medicine in the treatment of oropharyngeal candidiasis (OPC).

IF 5.5 2区医学 Q2 MICROBIOLOGY

Journal of Oral Microbiology Pub Date : 2025-10-21 eCollection Date: 2025-01-01 DOI:10.1080/20002297.2025.2572338

Shiqi Wang, Hongchen Wang, Wenfan Wei, Tianming Wang

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引用次数: 0

Abstract

Background: Oropharyngeal candidiasis (OPC) is a prevalent fungal infection primarily caused by Candida species, notably Candida albicans, posing significant health challenges. Traditional Chinese medicine (TCM) has gained attention due to its multifaceted pharmacological properties and lower incidence of adverse effects compared to conventional treatments.

Objective: This article aims to explore the application of TCM in OPC therapy and elucidate the potential molecular mechanisms underlying its efficacy.

Design: A comprehensive analysis of relevant studies and research findings was conducted to investigate the bioactive components of TCM and their mechanisms of action.

Results: The analysis reveals that TCM exerts beneficial effects through inhibition of fungal growth, regulation of immune responses, and enhancement of oral microecological balance.

Conclusions: TCM offers a holistic approach to managing OPC, leveraging its multifaceted mechanisms to address this common yet troublesome infection effectively.

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中药治疗口咽念珠菌病的分子机制。

背景：口咽念珠菌病（OPC）是一种流行的真菌感染，主要由念珠菌引起，特别是白色念珠菌，对健康构成重大挑战。与传统治疗方法相比，中医因其多方面的药理特性和较低的不良反应发生率而受到人们的关注。目的：探讨中药在OPC治疗中的应用，并阐明其可能的分子机制。设计：综合分析相关研究和研究成果，探讨中药生物活性成分及其作用机制。结果：分析表明中药通过抑制真菌生长、调节免疫反应、增强口腔微生态平衡等途径发挥有益作用。结论：中医提供了一种管理OPC的整体方法，利用其多方面的机制有效地解决这一常见而棘手的感染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Oral Microbiology MICROBIOLOGY-

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

12 weeks

期刊介绍： As the first Open Access journal in its field, the Journal of Oral Microbiology aims to be an influential source of knowledge on the aetiological agents behind oral infectious diseases. The journal is an international forum for original research on all aspects of ''oral health''. Articles which seek to understand ''oral health'' through exploration of the pathogenesis, virulence, host-parasite interactions, and immunology of oral infections are of particular interest. However, the journal also welcomes work that addresses the global agenda of oral infectious diseases and articles that present new strategies for treatment and prevention or improvements to existing strategies. Topics: ''oral health'', microbiome, genomics, host-pathogen interactions, oral infections, aetiologic agents, pathogenesis, molecular microbiology systemic diseases, ecology/environmental microbiology, treatment, diagnostics, epidemiology, basic oral microbiology, and taxonomy/systematics. Article types: original articles, notes, review articles, mini-reviews and commentaries