Hidden heroes in breast milk: The dual roles of phospholipids and sphingolipids in infant immunity and brain development

IF 2.1 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Early human development Pub Date : 2025-12-01 Epub Date: 2025-10-16 DOI:10.1016/j.earlhumdev.2025.106409

Yequan Xu , Xinkai Zhao , Zhenyu Ding , Shanyu Jiang , Renqiang Yu

引用次数: 0

Abstract

Compared with formula-fed infants, those who are breast-fed consistently demonstrate superior immune maturation, neurodevelopment, and cognitive performance, an advantage attributable, in part, to the complex bioactive lipidome of human milk. This review highlights the mechanistic roles of milk-derived phospholipids and sphingolipids in orchestrating these benefits. It critically evaluates their emerging clinical applications in preventing infection, allergy, and neurodevelopmental disorders, thereby establishing a framework for future strategies to optimize infant nutrition and developmental trajectories.

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母乳中隐藏的英雄：磷脂和鞘脂在婴儿免疫和大脑发育中的双重作用。

与配方奶喂养的婴儿相比，母乳喂养的婴儿始终表现出优越的免疫成熟、神经发育和认知能力，这一优势部分归因于母乳中复杂的生物活性脂质组。这篇综述强调了牛奶磷脂和鞘脂在协调这些益处中的机制作用。它批判性地评估了它们在预防感染、过敏和神经发育障碍方面的新临床应用，从而为优化婴儿营养和发育轨迹的未来战略建立了框架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Early human development 医学-妇产科学

CiteScore

4.40

自引率

4.00%

发文量

100

审稿时长

46 days

期刊介绍： Established as an authoritative, highly cited voice on early human development, Early Human Development provides a unique opportunity for researchers and clinicians to bridge the communication gap between disciplines. Creating a forum for the productive exchange of ideas concerning early human growth and development, the journal publishes original research and clinical papers with particular emphasis on the continuum between fetal life and the perinatal period; aspects of postnatal growth influenced by early events; and the safeguarding of the quality of human survival. The first comprehensive and interdisciplinary journal in this area of growing importance, Early Human Development offers pertinent contributions to the following subject areas: Fetology; perinatology; pediatrics; growth and development; obstetrics; reproduction and fertility; epidemiology; behavioural sciences; nutrition and metabolism; teratology; neurology; brain biology; developmental psychology and screening.