Zinc and Adipose Organ Dysfunction: Molecular Insights into Obesity and Metabolic Disorders.

IF 5.5 3区医学 Q1 NUTRITION & DIETETICS

Current Nutrition Reports Pub Date : 2025-10-24 DOI:10.1007/s13668-025-00709-1

Zahra Bahadoran, Fateme Ghafouri-Taleghani, Marijana Todorčević

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引用次数: 0

Abstract

Purpose of review: This review explores the emerging role of zinc (Zn) as a critical regulator of adipose organ structure and function, highlighting how Zn-related molecular networks contribute to the pathogenesis of obesity and associated metabolic disorders.

Recent findings: Experimental Zn-deficient models, and genetically-modified Zn-associated proteins, including Zn transporters [i.e., ZnTs (SLC30 family) and Zips (SLC39 family)], zinc-α₂-glycoprotein (ZAG), metallothioneins (MTs), and zinc finger proteins (ZFPs), demonstrate that Zn is indispensable for maintaining adipose organ integrity. Loss of these proteins disrupts adipogenesis, promotes adipocyte hypertrophy, induces macrophage infiltration and M₁ polarization, and drives pathological visceral fat expansion, resulting in systemic metabolic dysregulation. Zn plays a pivotal role in preserving adipose organ health and systemic metabolic balance. Further investigation is needed to elucidate depot-specific effects of Zn and the coordinated roles of Zn-handling proteins in adipose tissue, which may open new avenues for therapeutic strategies against obesity and metabolic diseases.

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锌和脂肪器官功能障碍：肥胖和代谢紊乱的分子见解。

综述目的：本文探讨了锌（Zn）作为脂肪器官结构和功能的关键调节因子的新作用，重点介绍了锌相关分子网络如何参与肥胖和相关代谢紊乱的发病机制。最近的研究发现：实验性缺锌模型和基因修饰的锌相关蛋白，包括锌转运蛋白[即ZnTs （SLC30家族）和Zips （SLC39家族）]、锌-α2-糖蛋白（ZAG）、金属硫蛋白（MTs）和锌指蛋白（ZFPs），表明锌对于维持脂肪器官的完整性是不可或缺的。这些蛋白的缺失破坏脂肪形成，促进脂肪细胞肥大，诱导巨噬细胞浸润和M1极化，驱动病理性内脏脂肪扩张，导致全身代谢失调。锌在维持脂肪器官健康和全身代谢平衡中起着关键作用。需要进一步研究阐明锌的仓库特异性作用以及锌处理蛋白在脂肪组织中的协调作用，这可能为肥胖和代谢性疾病的治疗策略开辟新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Nutrition Reports Agricultural and Biological Sciences-Food Science

CiteScore

7.70

自引率

2.00%

发文量

期刊介绍： This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.