Downshifting Luminescence Rare-Earth Nanoparticles for High-Resolution In Vivo Imaging at NIR IIb/c Window.

IF 9.1 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Letters Pub Date : 2025-10-23 DOI:10.1021/acs.nanolett.5c04506

Zihang Yu,Qianqian Ran,Mengfei Li,Shihui Wen,Haocheng Gao,Yuezhong Xian,Cuiling Zhang

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Abstract

Rare-earth nanoparticles (RENPs) operating in the NIR-IIb/c (1600-2000 nm) window hold great promise for bioimaging due to superior spatial resolution and deep tissue penetration. However, achieving high-brightness RENPs with precise emission control remains a significant challenge. Here, we report the rational design of highly Tm3+-doped α-phase core@shell@shell@shell RENPs with a cascade Nd3+-sensitized energy transfer architecture. Optimized RENPs exhibited a quantum yield (QY) of ∼23.5% in the NIR-IIb/c region under 980 nm excitation and achieved a QY of ∼11.3% under 808 nm excitation. Notably, the emission efficiency of highly Tm3+-doped systems (≥8%) is strongly dependent on the thickness of the intermediate Yb3+ shell, while low Tm3+ doping levels (≤4%) show minimal sensitivity to shell thickness. Furthermore, the engineered RENPs exhibit excellent biocompatibility and enable high-contrast deep-tissue vascular imaging in vivo. Our work provides a promising strategy for developing next-generation RENPs tailored for high-performance, noninvasive NIR-IIb/c bioimaging applications.

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降移发光稀土纳米粒子用于近红外IIb/c窗口的高分辨率体内成像。

稀土纳米颗粒（RENPs）在NIR-IIb/c （1600-2000 nm）窗口中工作，由于其优越的空间分辨率和深层组织穿透性，在生物成像方面具有很大的前景。然而，实现具有精确发射控制的高亮度renp仍然是一个重大挑战。在这里，我们报告了具有级联Nd3+敏化能量传递结构的高Tm3+掺杂α-相core@shell@shell@shell RENPs的合理设计。优化后的RENPs在980 nm激发下在NIR-IIb/c区域的量子产率（QY）为~ 23.5%，在808 nm激发下的QY为~ 11.3%。值得注意的是，高掺杂Tm3+体系的发射效率（≥8%）强烈依赖于中间Yb3+壳层的厚度，而低掺杂Tm3+体系（≤4%）对壳层厚度的敏感性最小。此外，工程RENPs表现出良好的生物相容性，能够在体内进行高对比度的深部组织血管成像。我们的工作为开发针对高性能、无创NIR-IIb/c生物成像应用的下一代RENPs提供了一个有前途的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.