Everolimus Induced Acute Fibrinous and Organizing Pneumonia (AFOP): A Rare Case Report.

Abstract

A variety of conditions have been associated with acute fibrinous and organizing pneumonia (AFOP), including autoimmune disorders, infectious agents, posttransplantation complications, and medications. Everolimus, an oral selective inhibitor of the mammalian target of rapamycin, is commonly used to manage metastatic malignancies such as breast cancer. Here, we describe a patient with a history of advanced breast cancer who developed AFOP secondary to everolimus, with the condition improving following discontinuation of the drug and initiation of steroid therapy.