Jingyi Wang, Kesen Liu, Hanhua Zhang, Wandi Cao, Yang Yan, Chengyue Wu, Xingya Wang, Xingmiao Yang, Xing Liu
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引用次数: 0
Abstract
The cGAS-STING axis is a central DNA-sensing pathway that initiates antiviral immune responses, yet the mechanisms by which viruses evade this defense system remain incompletely understood. Here, we identify the early protein EP0 of pseudorabies virus (PRV), a member of the Alphaherpesvirinae subfamily, as a viral virulence factor. Mechanistically, PRV EP0 suppresses cGAS-STING-mediated innate immunity by promoting the degradation of both cGAS and STING via the autophagy-lysosome pathway, thereby inhibiting downstream phosphorylation of TBK1 and IRF3. This degradation is strictly dependent on the structural integrity of EP0's functional domains. Notably, deletion of cGAS or STING significantly enhances replication of EP0-deficient PRV. Together, these findings establish PRV EP0 as a key antagonist of cGAS-STING-mediated innate immunity, offering insights that may inform the development of more effective vaccines and antiviral therapies.
期刊介绍：
Veterinary Microbiology is concerned with microbial (bacterial, fungal, viral) diseases of domesticated vertebrate animals (livestock, companion animals, fur-bearing animals, game, poultry, fish) that supply food, other useful products or companionship. In addition, Microbial diseases of wild animals living in captivity, or as members of the feral fauna will also be considered if the infections are of interest because of their interrelation with humans (zoonoses) and/or domestic animals. Studies of antimicrobial resistance are also included, provided that the results represent a substantial advance in knowledge. Authors are strongly encouraged to read - prior to submission - the Editorials (''Scope or cope'' and ''Scope or cope II'') published previously in the journal. The Editors reserve the right to suggest submission to another journal for those papers which they feel would be more appropriate for consideration by that journal.
Original research papers of high quality and novelty on aspects of control, host response, molecular biology, pathogenesis, prevention, and treatment of microbial diseases of animals are published. Papers dealing primarily with immunology, epidemiology, molecular biology and antiviral or microbial agents will only be considered if they demonstrate a clear impact on a disease. Papers focusing solely on diagnostic techniques (such as another PCR protocol or ELISA) will not be published - focus should be on a microorganism and not on a particular technique. Papers only reporting microbial sequences, transcriptomics data, or proteomics data will not be considered unless the results represent a substantial advance in knowledge.
Drug trial papers will be considered if they have general application or significance. Papers on the identification of microorganisms will also be considered, but detailed taxonomic studies do not fall within the scope of the journal. Case reports will not be published, unless they have general application or contain novel aspects. Papers of geographically limited interest, which repeat what had been established elsewhere will not be considered. The readership of the journal is global.
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