Vaccine Coverage Among People With Cystic Fibrosis: A National Multicenter Cross-Sectional Study in Israel.

IF 2.3 3区医学 Q1 PEDIATRICS

Pediatric Pulmonology Pub Date : 2025-10-01 DOI:10.1002/ppul.71343

Lior Tsviban, Nofar Amitai, Hagit Levine, Eyal Jacobi, Einat Shmueli, Miri Dotan, Huda Mussaffi, Hannah Blau, Patrick Stafler, Meir Mei-Zahav, Aielet Stolovas, Malena Cohen-Cymberknoh, Michal Gur, Ronen Bar-Yoseph, Karin Yaacoby-Bianu, Anna Ostrovsky, Galit Livnat, Noga Arwas, Inbal Golan-Tripto, Adi Dagan, Dario Prais, Ophir Bar-On

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引用次数: 0

Abstract

Background: Vaccines are a cornerstone of modern medicine, however, in some regions, low coverage is reported in patients with chronic diseases, including people with cystic fibrosis (pwCF), compared to the general population.

Methods: This retrospective multicenter study in Israel included pwCF born after January 1, 2000, and compared them to the general population. Vaccination data were collected from patient databases and the Ministry of Health reports for the general population.

Results: Out of 269 eligible pwCF aged 6 months to 23 years, a total of 173 were included. Coverage for the initial DTaP-IPV-HiB vaccine, administered in the first year of life, was similar between pwCF and the general population (92% compared with 96%, p = 0.23). In contrast, coverage for other routine vaccines given in the first year of life was significantly lower in pwCF: HAV (76% compared with 92%), HBV (85% compared with 96%), and the first dose of MMRV (85% compared with 97%) (all p < 0.001). Booster dose coverage for DTaP-IPV-HiB and MMRV, given at age 6-7 years, was also significantly reduced in pwCF (72% compared with 95% and 68% compared with 96% respectively, p < 0.001). Pneumococcal conjugate vaccine uptake was significantly lower in pwCF (61.8% vs. 94% in the general population p < 0.001), while the 23-valent pneumococcal vaccine was slightly more prevalent among pwCF compared to those with other chronic conditions, although uptake was low in both groups (15% vs. 10%, p = 0.001). Influenza vaccination rates during 3 seasons were significantly higher in pwCF (65%-70% vs. 20-27% in the general population, p < 0.001), whereas COVID-19 vaccine uptake was lower in adolescent pwCF compared to their general population peers (38.5% vs. 57.4%, p = 0.04).

Conclusion: Our study highlights suboptimal vaccine coverage among pwCF, particularly after the first year of life, affecting both routine early-life vaccines and booster doses. Greater awareness and proactive measures are needed to ensure adequate vaccination.

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囊性纤维化患者的疫苗覆盖率：以色列的一项全国性多中心横断面研究

背景：疫苗是现代医学的基石，然而，在一些地区，据报道，与一般人群相比，包括囊性纤维化（pwCF）患者在内的慢性疾病患者的覆盖率较低。方法：这项在以色列进行的回顾性多中心研究纳入了2000年1月1日后出生的pwCF，并将其与一般人群进行比较。疫苗接种数据是从患者数据库和卫生部针对一般人群的报告中收集的。结果：在269例符合条件的6个月至23岁的pwCF中，共有173例被纳入。在出生后第一年接种DTaP-IPV-HiB疫苗的覆盖率在pwCF和普通人群之间相似（92%对96%，p = 0.23）。相比之下，pwCF在出生后一年内接种其他常规疫苗的覆盖率明显较低：HAV（76%比92%）、HBV（85%比96%）和MMRV首剂（85%比97%）（均为p）。结论：我们的研究强调pwCF的疫苗覆盖率不理想，特别是在出生后一年内，影响常规早期疫苗和加强剂量。需要提高认识并采取积极措施，以确保充分的疫苗接种。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Pulmonology 医学-呼吸系统

CiteScore

6.00

自引率

12.90%

发文量

468

审稿时长

3-8 weeks

期刊介绍： Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases. PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.