Cognitive changes preceding Parkinson's disease: a systematic review and meta-analysis of prospective population-based studies.

IF 4.5 2区医学 Q2 GERIATRICS & GERONTOLOGY

Frontiers in Aging Neuroscience Pub Date : 2025-10-07 eCollection Date: 2025-01-01 DOI:10.3389/fnagi.2025.1627221

Noelia Peña Arauzo, Christoph Theyer, Florian Krismer, Atbin Djamshidian, Werner Poewe, Corinne Horlings, Beatrice Heim, Laura Zamarian, Philipp Mahlknecht

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Abstract

Introduction: Various non-motor symptoms have been studied as part of the prodromal phase of Parkinson's disease (PD). However, studies assessing cognitive changes are scarce.

Methods: We systematically searched PubMed and SCOPUS to identify prospective, population-based studies that reported on cognitive performance in individuals without PD at baseline, the incidence of PD at follow-up, and comparisons of cognitive performance between participants who developed PD and controls.

Results: Twelve studies were identified, including a total of 524,807 participants, of whom 2,939 developed PD. Four studies found differences in global cognition and a meta-analysis showed that individuals who developed PD scored 0.3 points lower than controls on the Mini-Mental State Examination at baseline. Cognitive changes were most frequently observed in tests of executive function, processing-speed and attention, and less frequently in visuospatial/visuoconstructive skills and memory. Due to the heterogeneity of the assessment methods used, it was not possible to conduct further meta-analyses.

Conclusions: Cognitive changes may be part of the clinical picture in prodromal PD cohorts derived from the general population. Further population-based studies with large samples and long-term follow-up are needed to better understand their extent and significance.

Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024547252, identifier: CRD42024547252.

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帕金森病前的认知变化：前瞻性人群研究的系统回顾和荟萃分析

各种非运动症状作为帕金森氏病（PD）前驱期的一部分已被研究。然而，评估认知变化的研究很少。方法：我们系统地检索PubMed和SCOPUS，以确定前瞻性的、基于人群的研究，这些研究报告了基线时无PD个体的认知表现，随访时PD的发病率，以及PD参与者和对照组之间认知表现的比较。结果：共纳入12项研究，包括524,807名参与者，其中2,939名发展为PD。四项研究发现了全球认知的差异，一项荟萃分析显示，患有PD的个体在基线时的迷你精神状态检查得分比对照组低0.3分。在执行功能、处理速度和注意力测试中最常观察到认知变化，而在视觉空间/视觉构建技能和记忆测试中不太常见。由于所用评估方法的异质性，不可能进行进一步的meta分析。结论：认知改变可能是来自普通人群的PD前驱队列临床表现的一部分。需要进一步以大样本和长期随访的人群为基础的研究，以更好地了解其范围和意义。系统评价注册：https://www.crd.york.ac.uk/PROSPERO/view/CRD42024547252，标识符：CRD42024547252。

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来源期刊

Frontiers in Aging Neuroscience GERIATRICS & GERONTOLOGY-NEUROSCIENCES

CiteScore

6.30

自引率

8.30%

发文量

1426

期刊介绍： Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.