Himanshu Sekhar Panda, Mrunali D. Dhokne, Sumit Thakur, Nisha Singh, Ashok Kumar Datusalia, Jiban Jyoti Panda
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引用次数: 0
Abstract
Alzheimer's Disease
BDNF-loaded amino acid–catecholamine hybrid nanoparticles (B-EDTNPs) are capable of crossing the blood–brain barrier (BBB) to efficiently deliver BDNF. These nanoparticles inhibit Aβ fibrillization, promote amyloid plaque clearance, reduce oxidative stress, and protect neuronal cells from fibril-induced damage. In SH-SY5Y neuroblastoma cells, B-EDTNPs significantly improve cell viability against FF and Aβ (1-42) toxicity. Promising outcomes in AD mouse model are shown by effectively reducing amyloid plaque accumulation, suppress inflammatory markers like NF-κB and TNF-α, and restore cognitive functions. More in article number 2411701, Ashok Kumar Datusalia, Jiban Jyoti Panda, and co-workers.
期刊介绍：
Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments.
With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology.
Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.
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