Front Cover: Structural and Molecular Basis of Zinc-Induced Primary Nucleation of Polymorphic Amyloid-β Dimers (Eur. J. Inorg. Chem. 30/2025)

Abstract

The Front Cover presents polymorphic zinc-bound amyloid-β (Aβ) dimer models, derived from an extensive computational study of the molecular basis of zinc-induced Aβ primary nucleation. By revealing how zinc ions influence Aβ dimer structure and stability, the Research Article by K. Abramov Harpaz and Y. Miller (DOI: 10.1002/ejic.202500331) provides new insights into the mechanisms driving early aggregation events in Alzheimer’s disease, offering a molecular framework for future therapeutic strategies.