The evolution of nanomedicine: The rise of next-generation nanomaterials in cancer nanomedicine

IF 12.5 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2025-10-22 DOI:10.1126/sciadv.adx1576

Helen Forgham, Yixin Chang, Yao Wang, Jiayuan Zhu, Liwei Liu, Heather Biggs, Aleksandr Kakinen, Yuhao Jiang, Xinru You, Kristofer J. Thurecht, Shaohua Ma, Lining Arnold Ju, Wei Tao, Thomas P. Davis, Joyce Y. Wong, Ruirui Qiao

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Abstract

The nanomedicine field continues to gain momentum, with several groundbreaking clinical trials underway. However, despite the promise of advanced antifouling nanoparticles incorporating poly(ethylene glycol)—a key component in the development of COVID-19 vaccines—the clinical translation of nanomedicine remains limited. This is primarily due to the relatively low delivery efficacy, with passive targeting relying on the enhanced permeability and retention effect, and active targeting leading to only modest improvements in target tissue accumulation. Improving the targeting, biocompatibility, and functionality of nanoparticles has the potential to create more effective, personalized, and minimally invasive therapies. This review aims to highlight the rise of a previously unidentified order of immune-minded nanomaterials and explores how mechanobiological principles and biomechanical nanotools are revolutionizing our understanding of nano-bio interactions in relation to disease. By considering mechanical properties such as stiffness, surface topology, and behavior under physiological flow conditions, researchers can better engineer nanoparticles for improved therapeutic outcomes.

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纳米医学的发展：新一代纳米材料在癌症纳米医学中的兴起。

纳米医学领域继续获得动力，有几个开创性的临床试验正在进行中。然而，尽管含有聚乙二醇（COVID-19疫苗开发中的关键成分）的先进防污纳米颗粒前景光明，但纳米药物的临床转化仍然有限。这主要是由于相对较低的递送效率，被动靶向依赖于增强的渗透性和滞留效应，而主动靶向只能适度改善靶组织的积累。提高纳米颗粒的靶向性、生物相容性和功能，有可能创造出更有效、个性化和微创的治疗方法。这篇综述的目的是强调以前未知的免疫意识纳米材料的兴起，并探讨机械生物学原理和生物力学纳米工具如何彻底改变我们对与疾病相关的纳米生物相互作用的理解。通过考虑机械性能，如刚度、表面拓扑结构和生理流动条件下的行为，研究人员可以更好地设计纳米颗粒，以改善治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.