Cardiometabolic risk accounts for associations between personality and cognition in midlife.

IF 2.6 4区心理学 Q2 CLINICAL NEUROLOGY

Journal of the International Neuropsychological Society Pub Date : 2025-10-21 DOI:10.1017/S1355617725101288

Alina Lesnovskaya, Rebecca G Reed, Chelsea M Stillman, Janine D Flory, Kirk I Erickson, Anna L Marsland, Aidan G C Wright, Matthew F Muldoon, Stephen B Manuck

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引用次数: 0

Abstract

Objective: Five-Factor Model (FFM) personality traits are associated with cognitive function, however, biological pathways accounting for these relations are not well understood. Here, we examined associations between individual FFM traits (self- and informant-reported) and cognitive function (episodic memory, executive control, and working memory), and the indirect effect of a latent index of cardiometabolic risk (composed of adiposity, glycemic control, blood pressure, blood lipids, and inflammation) in a midlife sample.

Method: Participants included 856 volunteers (M = 44.6 ± 6.9 years, range: 30 - 54; Female 54%; Caucasian 85%) from the Adult Health and Behavior (AHAB) registry. Structural equation models were used to: (1) regress cognitive performance on FFM traits and (2) test indirect effects of cardiometabolic risk. Age, sex, and race were included as covariates in all models.

Results: Lower Neuroticism, higher Openness, and higher Agreeableness were significantly associated with better performance in each cognitive domain, and higher Conscientiousness was associated with better working memory. Associations between these traits and executive control were accounted for by a significant indirect effect of lower cardiometabolic risk, and in component-specific analyses, by indirect effects of adiposity and systemic inflammation.

Conclusions: Overall, FFM personality traits were associated with multiple domains of cognitive performance, which, in the case of executive control, was partially explained by differences in cardiometabolic risk. Future investigations should examine whether these pathways account for longitudinal change in cognition.

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心脏代谢风险解释了中年人格和认知之间的关联。

目的：五因素模型（FFM）人格特征与认知功能之间存在着一定的联系，但其生物学机制尚不清楚。在这里，我们研究了中年样本中个体FFM特征（自我报告和举证者报告）与认知功能（情景记忆、执行控制和工作记忆）之间的关联，以及潜在的心脏代谢风险指数（由肥胖、血糖控制、血压、血脂和炎症组成）的间接影响。方法：参与者包括来自成人健康与行为（AHAB）登记处的856名志愿者（M = 44.6±6.9岁，年龄范围：30 - 54岁；女性54%；高加索人85%）。采用结构方程模型：(1)回归认知表现对FFM特征的影响；(2)检验心血管代谢风险的间接影响。在所有模型中，年龄、性别和种族均作为协变量。结果：较低的神经质、较高的开放性和较高的亲和性与各认知领域的较好表现显著相关，较高的责任心与较好的工作记忆显著相关。这些特征和执行控制之间的关联可以通过降低心脏代谢风险的显著间接影响来解释，在成分特异性分析中，可以通过肥胖和全身性炎症的间接影响来解释。结论：总体而言，FFM人格特质与认知表现的多个领域相关，在执行控制的情况下，这部分可以通过心脏代谢风险的差异来解释。未来的研究应该检查这些通路是否能解释认知的纵向变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the International Neuropsychological Society 医学-精神病学

CiteScore

5.40

自引率

3.80%

发文量

185

审稿时长

4-8 weeks

期刊介绍： The Journal of the International Neuropsychological Society is the official journal of the International Neuropsychological Society, an organization of over 4,500 international members from a variety of disciplines. The Journal of the International Neuropsychological Society welcomes original, creative, high quality research papers covering all areas of neuropsychology. The focus of articles may be primarily experimental, applied, or clinical. Contributions will broadly reflect the interest of all areas of neuropsychology, including but not limited to: development of cognitive processes, brain-behavior relationships, adult and pediatric neuropsychology, neurobehavioral syndromes (such as aphasia or apraxia), and the interfaces of neuropsychology with related areas such as behavioral neurology, neuropsychiatry, genetics, and cognitive neuroscience. Papers that utilize behavioral, neuroimaging, and electrophysiological measures are appropriate. To assure maximum flexibility and to promote diverse mechanisms of scholarly communication, the following formats are available in addition to a Regular Research Article: Brief Communication is a shorter research article; Rapid Communication is intended for "fast breaking" new work that does not yet justify a full length article and is placed on a fast review track; Case Report is a theoretically important and unique case study; Critical Review and Short Review are thoughtful considerations of topics of importance to neuropsychology and include meta-analyses; Dialogue provides a forum for publishing two distinct positions on controversial issues in a point-counterpoint format; Special Issue and Special Section consist of several articles linked thematically; Letter to the Editor responds to recent articles published in the Journal of the International Neuropsychological Society; and Book Review, which is considered but is no longer solicited.