Neural correlates of vestibular adaptation in cosmonauts after long duration spaceflight.

IF 4.1 1区物理与天体物理 Q1 MULTIDISCIPLINARY SCIENCES

npj Microgravity Pub Date : 2025-10-20 DOI:10.1038/s41526-025-00528-2

Catho Schoenmaekers, Steven Jillings, Sepehr Mortaheb, Dmitrii Glukhikh, Ivan Naumov, Elena Tomilovskaya, Ilya Rukavishnikov, Ekaterina Pechenkova, Alexandra Ryabova, Lyudmila Makovskaya, Inna Nosikova, Peter Zu Eulenburg, Floris L Wuyts

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引用次数: 0

Abstract

Long-duration spaceflight affects otolith-mediated ocular counter-roll (OCR) and brain function, but the relationship between these changes is unclear. This study examines whether OCR changes correlate with functional connectivity (FC) changes in the vestibular network in the same cosmonauts after a long-duration (6-month) spaceflight mission. Using a human vestibular atlas, we found that changes in FC between the right operculum (OP2_PIVC) and inferior parietal lobule (IPL, area PGp and PGa) were positively correlated with OCR changes. First-time flyers showed a greater decrease in OCR, linked to more significant FC reductions. Irrespective of the OCR, increased FC was observed postflight between the left visual cingulate cortex (CSv) and the anterior cingulate cortex (ACC, area 33), superior parietal lobule (SPL, area 5C), and thalamus (pulvinar), and between the right OP2_PIVC and SPL (area 5Ci). Secondly, decreased FC was observed between the left OP2_PIVC and the IPL (PGp) and SPL (area 7A). Additionally, increased FC postflight was observed between the left lateral sensorimotor area (LSM) and IPL (area PGp), and between the right lateral visual area (LVA) and cerebellum (Crus 1, Lobule VI). These findings suggest sensory reweighting and sensory system reorganization after long-duration spaceflight.

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长时间太空飞行后宇航员前庭适应的神经相关研究。

长时间的太空飞行影响耳石介导的眼反滚（OCR）和脑功能，但这些变化之间的关系尚不清楚。本研究探讨了在长时间（6个月）的太空飞行任务后，同一名宇航员前庭神经网络的OCR变化是否与功能连接（FC）变化相关。利用人类前庭图谱，我们发现右脑盖（OP2_PIVC）和下顶叶（IPL，区域PGp和PGa）之间的FC变化与OCR变化呈正相关。首次飞行者的OCR下降幅度更大，这与更显著的FC减少有关。无论OCR如何，飞行后在左侧视觉扣带皮层（CSv）和前扣带皮层（ACC， 33区）、顶叶上小叶（SPL， 5C区）和丘脑（pulvinar）之间以及右侧OP2_PIVC和SPL （5Ci区）之间观察到FC增加。其次，左侧OP2_PIVC与IPL （PGp）和SPL （7A区）之间的FC减少。此外，飞行后在左侧感觉运动区（LSM）和IPL区（PGp区）之间，以及右侧视觉区（LVA）和小脑（1脚，6小叶）之间观察到FC增加。这些发现提示了长时间太空飞行后感觉系统的重新调整和重组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

npj Microgravity Physics and Astronomy-Physics and Astronomy (miscellaneous)

CiteScore

7.30

自引率

7.80%

发文量

审稿时长

9 weeks

期刊介绍： A new open access, online-only, multidisciplinary research journal, npj Microgravity is dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms.