Prenatal corticosteroid use and offspring neurological outcomes

IF 2.8 3区医学 Q3 NEUROSCIENCES

Neurotoxicology and teratology Pub Date : 2025-11-01 Epub Date: 2025-10-20 DOI:10.1016/j.ntt.2025.107564

Yun Yan , Junyi Wang , Xiaoping Lei

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引用次数: 0

Abstract

Prenatal use of synthetic corticosteroids has been widely applied in preventing respiratory distress syndrome in preterm infants. In recent years, research has begun to focus on the effects of Antenatal Corticosteroids(ACS) on the short-term and long-term neurological development of offspring. This review summarizes the direct and potential effects of ACS on offspring neurological outcomes, including cognitive function, behavioral problems, and neurodevelopmental disorders. Studies have shown that prenatal corticosteroid exposure may be associated with improved short-term neurological outcomes in extremely preterm infants. However, the benefits on near- and long-term outcomes in late preterm and full-term infants remain inconclusive and controversial due to a lack of robust evidence. This article explores the potential effects of exposure timing and different dosages on offspring neurological outcomes, and emphasizes the need for further research to optimize the indications for ACS use. This will ensure its benefits in preterm complications while minimizing its potential negative impact on offspring neurodevelopment.

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产前皮质类固醇使用与后代神经预后。

产前使用合成皮质类固醇已被广泛应用于预防早产儿呼吸窘迫综合征。近年来，人们开始关注产前皮质类固醇（ACS）对后代短期和长期神经发育的影响。本文综述了ACS对后代神经系统预后的直接和潜在影响，包括认知功能、行为问题和神经发育障碍。研究表明，产前皮质类固醇暴露可能与极早产儿短期神经预后的改善有关。然而，由于缺乏强有力的证据，对晚期早产儿和足月婴儿的近期和长期结果的益处仍然是不确定和有争议的。本文探讨了暴露时间和不同剂量对后代神经预后的潜在影响，并强调需要进一步研究以优化ACS的适应症。这将确保其对早产儿并发症的益处，同时最大限度地减少其对后代神经发育的潜在负面影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurotoxicology and teratology 医学-毒理学

CiteScore

5.60

自引率

10.30%

发文量

审稿时长

58 days

期刊介绍： Neurotoxicology and Teratology provides a forum for publishing new information regarding the effects of chemical and physical agents on the developing, adult or aging nervous system. In this context, the fields of neurotoxicology and teratology include studies of agent-induced alterations of nervous system function, with a focus on behavioral outcomes and their underlying physiological and neurochemical mechanisms. The Journal publishes original, peer-reviewed Research Reports of experimental, clinical, and epidemiological studies that address the neurotoxicity and/or functional teratology of pesticides, solvents, heavy metals, nanomaterials, organometals, industrial compounds, mixtures, drugs of abuse, pharmaceuticals, animal and plant toxins, atmospheric reaction products, and physical agents such as radiation and noise. These reports include traditional mammalian neurotoxicology experiments, human studies, studies using non-mammalian animal models, and mechanistic studies in vivo or in vitro. Special Issues, Reviews, Commentaries, Meeting Reports, and Symposium Papers provide timely updates on areas that have reached a critical point of synthesis, on aspects of a scientific field undergoing rapid change, or on areas that present special methodological or interpretive problems. Theoretical Articles address concepts and potential mechanisms underlying actions of agents of interest in the nervous system. The Journal also publishes Brief Communications that concisely describe a new method, technique, apparatus, or experimental result.