Isoflavones improve vaginal atrophy, skin health, and sex-related hormones in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.

IF 3 3区医学 Q1 OBSTETRICS & GYNECOLOGY

Menopause: The Journal of The North American Menopause Society Pub Date : 2025-12-01 DOI:10.1097/GME.0000000000002619

Mingkwan Na Takuathung, Ratchanon Inpan, Kantirat Yaja, Wilawun Ruansit, Supanimit Teekachunhatean, Nut Koonrungsesomboon

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引用次数: 0

Abstract

Importance: Isoflavones, natural bioactive compounds with estrogen-like properties, are increasingly used by postmenopausal women to manage menopausal symptoms. However, research on their efficacy has produced inconsistent results, necessitating a comprehensive review to guide clinical practice.

Objective: To evaluate the effects of isoflavone interventions on vaginal atrophy, skin health, and sex-related hormone levels in postmenopausal women through a systematic review and meta-analysis of randomized controlled trials.

Evidence review: A systematic literature search was conducted in PubMed, Embase, Scopus, and the Cochrane Library databases from inception to January 2025. Eligible studies were randomized controlled trials investigating isoflavone interventions in postmenopausal women. Effect sizes were summarized as standardized mean differences (SMDs) with 95% CIs using a random-effects model. The risk of bias was assessed using the Risk of Bias 2 tool.

Findings: The analysis included 47 studies comprising 2,657 participants. Isoflavone interventions significantly reduced vaginal dryness (SMD=-1.147; 95% CI, -2.077 to -0.216; P =0.016; I2 =95.4%) and increased the vaginal maturation value (SMD=0.605; 95% CI, 0.087 to 1.123; P =0.022; I2 =88.7%). Improvements in skin health were observed, including reduced skin roughness measure R2 (SMD=-0.209; 95% CI, -0.389 to -0.029; P =0.028; I²=0.0%) and wrinkle surface (SMD=-0.342; 95% CI, -0.560 to -0.124; P =0.002; I2 =0.0%). Isoflavones also significantly increased estradiol levels (SMD=0.247; 95% CI, 0.059 to 0.435; P =0.010; I2 =60.5%).

Conclusions and relevance: Isoflavone interventions effectively manage vaginal atrophy in postmenopausal women and show potential for improving skin health and sex-related hormone levels. These findings underscore the therapeutic value of isoflavones while emphasizing the need for further research, particularly regarding their effects on skin health.

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异黄酮改善绝经后妇女阴道萎缩、皮肤健康和性激素：一项随机对照试验的系统回顾和荟萃分析

重要性：异黄酮，具有雌激素样特性的天然生物活性化合物，越来越多地被绝经后妇女用于治疗更年期症状。然而，对其疗效的研究产生了不一致的结果，需要进行全面的审查以指导临床实践。目的：通过随机对照试验的系统回顾和荟萃分析，评价异黄酮干预对绝经后妇女阴道萎缩、皮肤健康和性激素水平的影响。证据回顾：系统地检索PubMed、Embase、Scopus和Cochrane图书馆数据库，检索时间从成立到2025年1月。符合条件的研究是调查异黄酮干预绝经后妇女的随机对照试验。使用随机效应模型将效应量总结为95% ci的标准化平均差异（SMDs）。使用risk of bias 2工具评估偏倚风险。研究结果：该分析包括47项研究，2,657名参与者。异黄酮干预显著降低阴道干爽（SMD=-1.147; 95% CI, -2.077 ~ -0.216； P=0.016; I2=95.4%），提高阴道成熟值（SMD=0.605; 95% CI, 0.087 ~ 1.123； P=0.022; I2= 88.7%）。观察到皮肤健康状况的改善，包括皮肤粗糙度测量R2降低（SMD=-0.209; 95% CI, -0.389至-0.029；P=0.028; I²=0.0%）和皱纹表面（SMD=-0.342; 95% CI, -0.560至-0.124；P=0.002; I2=0.0%）。异黄酮也显著提高雌二醇水平（SMD=0.247; 95% CI, 0.059 ~ 0.435； P=0.010; I2=60.5%）。结论和相关性：异黄酮干预有效地控制绝经后妇女阴道萎缩，并显示出改善皮肤健康和性激素水平的潜力。这些发现强调了异黄酮的治疗价值，同时强调了进一步研究的必要性，特别是关于它们对皮肤健康的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Menopause: The Journal of The North American Menopause Society 医学-妇产科学

CiteScore

5.40

自引率

7.40%

发文量

330

审稿时长

3-8 weeks

期刊介绍： Menopause, published monthly, provides a forum for new research, applied basic science, and clinical guidelines on all aspects of menopause. The scope and usefulness of the journal extend beyond gynecology, encompassing many varied biomedical areas, including internal medicine, family practice, medical subspecialties such as cardiology and geriatrics, epidemiology, pathology, sociology, psychology, anthropology, and pharmacology. This forum is essential to help integrate these areas, highlight needs for future research, and enhance health care.