{"title":"The complicated relationship between inflammation and metabolic dysfunction.","authors":"Shima Abtin, Tayebeh Ziveh, Mostafa Rezaee-Tavirani","doi":"10.1007/s40200-025-01729-y","DOIUrl":null,"url":null,"abstract":"<p><p>The prevalence of metabolic diseases, including obesity, type 2 diabetes, cardiovascular diseases, metabolic syndrome, and non-alcoholic fatty liver disease, is rising steadily and has emerged as a global health issue. Evidence indicates that chronic inflammation plays a crucial role in the development and progression of metabolic diseases. This review article addresses the intricate and reciprocal link between chronic inflammation and disrupted glucose and lipid metabolism. Furthermore, it explores the influence of factors such as the gut microbiome, socio-psychological variables, and aging. The article ultimately discusses future research directions and the need for a better understanding of the complexities between inflammation and metabolism. Addressing these factors could provide effective strategies for preventing and managing metabolic disorders, improving quality of life and public health.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"24 2","pages":"237"},"PeriodicalIF":2.1000,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12535578/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Diabetes and Metabolic Disorders","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s40200-025-01729-y","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/12/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
The prevalence of metabolic diseases, including obesity, type 2 diabetes, cardiovascular diseases, metabolic syndrome, and non-alcoholic fatty liver disease, is rising steadily and has emerged as a global health issue. Evidence indicates that chronic inflammation plays a crucial role in the development and progression of metabolic diseases. This review article addresses the intricate and reciprocal link between chronic inflammation and disrupted glucose and lipid metabolism. Furthermore, it explores the influence of factors such as the gut microbiome, socio-psychological variables, and aging. The article ultimately discusses future research directions and the need for a better understanding of the complexities between inflammation and metabolism. Addressing these factors could provide effective strategies for preventing and managing metabolic disorders, improving quality of life and public health.
期刊介绍：
Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.
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