Obstructive sleep apnea and aging of the cardiovascular system: a multidimensional analysis of the mechanisms involved.

IF 4.1 4区医学 Q1 GERIATRICS & GERONTOLOGY

Biogerontology Pub Date : 2025-10-21 DOI:10.1007/s10522-025-10337-5

Xiaolin Hao, Yan Li, Xiaoling Gao

引用次数: 0

Abstract

Emerging evidence has revealed a strong association between obstructive sleep apnea (OSA) and aging. Considering the critical role of the cardiovascular system, this review explores the key mechanisms linking OSA to cardiovascular aging through a focus on chronic intermittent hypoxia (CIH) -induced oxidative stress and chronic inflammation. Specifically, we examine six key pathways: (1) cellular senescence, (2) mitochondrial dysfunction, (3) metabolic dysregulation, (4) telomere attrition, (5) impaired intercellular communication, and (6) adipose tissue senescence. These insights provide a foundation for identifying novel interventions and therapeutic targets to mitigate or even reverse cardiovascular aging.

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阻塞性睡眠呼吸暂停和心血管系统老化：涉及机制的多维分析。

越来越多的证据表明，阻塞性睡眠呼吸暂停（OSA）与衰老之间存在密切联系。考虑到心血管系统的关键作用，本文通过关注慢性间歇性缺氧（CIH）诱导的氧化应激和慢性炎症，探讨OSA与心血管衰老的关键机制。具体来说，我们研究了六个关键途径：(1)细胞衰老，(2)线粒体功能障碍，(3)代谢失调，(4)端粒磨损，(5)细胞间通讯受损，(6)脂肪组织衰老。这些见解为确定新的干预措施和治疗靶点以减轻甚至逆转心血管衰老提供了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biogerontology 医学-老年医学

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

>12 weeks

期刊介绍： The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.