Jackson A. Roberts, Mitchell S. V. Elkind, Minghua Liu, Stephanie Assuras, Bonnie E. Levin, Vanessa Guzman, Tatjana Rundek, Jose Gutierrez
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引用次数: 0
Abstract
INTRODUCTION
The Northern Manhattan Study (NOMAS) previously identified that a combined infectious disease exposure index correlates with impaired cognitive performance in older adults.
METHODS
We extended these findings by examining the association of serological titers of five common infectious diseases (herpes simplex virus [HSV] 1 and 2, cytomegalovirus [CMV], Chlamydia pneumoniae, and Helicobacter Pylori) with domain-specific cognitive performance and incident cognitive impairment and dementia in 593 community-dwelling older adults. We performed confounder-adjusted mixed linear regression between infectious serologies and longitudinal cognitive performance.
RESULTS
CMV and HSV-2 serologies were associated with impaired executive function, whereas C. pneumoniae serology was associated with impaired performance on language testing. In univariate Cox proportional hazard models, CMV serologies were associated with incident cognitive impairment and dementia.
DISCUSSION
CMV seropositivity may accelerate domain-specific cognitive worsening and could confer increased risk for cognitive impairment and dementia, warranting further evaluation in observational and experimental datasets.
Highlights
Infectious exposures may contribute to neurodegeneration and risk of cognitive impairment.
Cytomegalovirus (CMV) and herpes simplex virus 2 exposure were associated with impaired executive function.
Chlamydia pneumoniae was associated with decreased performance on language testing.
CMV may be associated with incident cognitive impairment and dementia.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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