Molecular engineering of NIR AIE probes for cell membrane-targeted cancer phototheranostics.

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-10-21 DOI:10.1039/d5cc04637h

Chengwei Tang, Wenman Li, Huixuan Tang, Yuanyuan You, Yuxun Ding, Dingyuan Yan, Dong Wang, Xiaohui Chen

引用次数: 0

Abstract

A finely engineered NIR AIE probe, namely TTTVPHE, was synthesized with dithieno[2,3-b:2',3'-d]thiophene to bridge triphenylamine and pyridinium units for cell membrane-targeted cancer phototheranostics. TTTVPHE has significant advantages such as strong cell membrane binding affinity, NIR-I/II emission, superior AIE characteristics, and excellent type I/II ROS generation ability.

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近红外AIE探针用于细胞膜靶向肿瘤光疗的分子工程研究。

采用二噻吩[2,3-b:2′，3′-d]合成了一种精细工程的近红外AIE探针TTTVPHE，用于三苯胺和吡啶单元的桥接，用于细胞膜靶向癌症光疗。TTTVPHE具有较强的细胞膜结合亲和力、NIR-I/II发射、优越的AIE特性和优异的I/II型ROS生成能力等显著优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.