A Novel Zinc(II) Complex for Sonodynamic Therapy Induces Pyroptosis of Breast Cancer Cells and Enhances Anti-Tumor Immune Response.

Abstract

Zinc(II) complexes have emerged as promising antitumor agents due to their favorable biosafety and biocompatibility, and demonstrated effectiveness in photodynamic therapy (PDT). However, their therapeutic potential is limited by the poor tissue penetration of PDT agents. Herein, a novel zinc(II) complex designed for sonodynamic therapy (SDT), capable of producing substantial amounts of singlet oxygen upon ultrasonic activation, is introduced. This sonosensitizer effectively induces pyroptosis in breast cancer cells, significantly promoting the antitumor immune response. This work represents the first exploration of zinc(II) complexes in SDT, establishing a new avenue for enhanced therapeutic outcomes against breast cancer.