Relación entre isoformas de apolipoproteína(a) y niveles de lipoproteína(a) en pacientes con síndrome coronario agudo

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

Clinica e Investigacion en Arteriosclerosis Pub Date : 2026-03-01 Epub Date: 2025-10-18 DOI:10.1016/j.arteri.2025.500870

Rosa Fernández-Olmo , Jesús Lara Mariscal , Ana García Ruano , Alberto Cordero , Juan Manuel Castillo Casas , Diego Franco

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Abstract

Lp(a) is a cardiovascular risk factor influenced by the LPA gene and apo(a) isoforms. Their relationship is not always linear and there are discordant phenotypes, for this reason in our work we evaluated the association between apo(a) isoforms and Lp(a) levels in patients with acute coronary syndrome (ACS). To this end, 43 patients with ACS and Lp(a) > 50 mg/dL were studied. The isoforms were characterized in 12 bands by Western blotting. The association between bands and Lp(a) concentrations was evaluated by statistical analysis. It was observed that the intermediate molecular weight bands (b5-b8) were the most frequent, with band 8 predominating. No significant association was found between isoform size and Lp(a) levels (P > .05). We conclude that in this cohort no correlation was observed between apo(a) and Lp(a) isoforms. Other genetic or regulatory mechanisms could explain the observed variability, supporting the need for larger studies.

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急性冠状动脉综合征患者载脂蛋白(a)亚型与脂蛋白(a)水平的关系

Lp(a)是受LPA基因和载脂蛋白(a)亚型影响的心血管危险因素。它们的关系并不总是线性的，并且存在不一致的表型，因此在我们的工作中，我们评估了急性冠脉综合征（ACS）患者载脂蛋白(a)亚型和脂蛋白(a)水平之间的关系。为此，我们对43例ACS患者进行了Lp(a) bb0 50mg/dL的研究。Western blotting将其分为12个条带。通过统计分析评估波段与Lp(a)浓度之间的关系。结果表明，中间分子量带（b5 ~ b8）最为常见，以8带居多。异构体大小与Lp(a)水平无显著相关性（P < 0.05）。我们得出结论，在这个队列中，载脂蛋白(a)和脂蛋白(a)亚型之间没有相关性。其他遗传或调节机制可以解释观察到的差异，支持需要进行更大规模的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinica e Investigacion en Arteriosclerosis PERIPHERAL VASCULAR DISEASE-

CiteScore

3.20

自引率

6.20%

发文量

审稿时长

40 days

期刊介绍： La publicación idónea para acceder tanto a los últimos originales de investigación como a formación médica continuada sobre la arteriosclerosis y su etiología, epidemiología, fisiopatología, diagnóstico y tratamiento. Además, es la publicación oficial de la Sociedad Española de Arteriosclerosis.