γδ T cells and head and neck squamous cell carcinoma.

Abstract

Head and neck squamous cell carcinoma (HNSCC) is a prevalent and aggressive malignant tumor with poor clinical prognosis. The immune system plays a critical role in tumor surveillance and response to therapy. Among various immune cell populations, γδ T (γδ T) cells, a unique subset of lymphocytes, have emerged as significant participants in the anti-tumor immune response and have attracted extensive attention in recent studies. This chapter discusses the unique properties of γδ T cells, their role in HNSCC, and evaluates their potential value as therapeutic targets for HNSCC.