Cycloastragenol Exerts an Antiapoptotic Effect on Human Lymphocytes under UV-Irradiation

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology

Biophysics Pub Date : 2025-10-20 DOI:10.1134/S0006350925700575

M. A. Nakvasina, V. G. Artyukhov, M. G. Holyavka, I. A. Koltakov, E. I. Korpusova, N. G. Saraji

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Abstract

Changes in the levels of some markers of apoptosis (lipid asymmetry of plasma membranes, production of reactive oxygen species, nitric oxide, and the concentration of ionized calcium) of human blood lymphocytes modified by exposure to hydrogen peroxide (10^–5 mol/L) and UV light (254 nm, 1510 J/m²) in the presence of cycloastragenol (10^–8–10^–5 mol/L) were studied. The intensity of apoptotic lymphocyte death processes was found to decrease after UV-light exposure in the presence of cycloastragenol (10^–8 mol/L). The cytoprotective effect of cycloastragenol on lymphocytes was found to be due to a decrease in the level of intracellular reactive oxygen species and calcium ions and an increase in the activity of catalase and glutathione reductase and nitric oxide production. Possible mechanisms of cycloastragenol action as a regulator of apoptotic death of lymphocytes induced by UV radiation and hydrogen peroxide exposure are discussed.

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环黄芪醇对紫外线照射下人淋巴细胞的抗凋亡作用

研究了环黄芪醇（10-8-10-5 mol/L）存在下，过氧化氢（10-5 mol/L）和紫外光（254 nm, 1510 J/m2）对人血液淋巴细胞凋亡标志物（质膜脂质不对称、活性氧产生、一氧化氮和电离钙浓度）的影响。在环黄芪醇（10-8 mol/L）的紫外线照射下，淋巴细胞凋亡过程的强度降低。发现环黄芪醇对淋巴细胞的细胞保护作用是由于降低细胞内活性氧和钙离子的水平，增加过氧化氢酶和谷胱甘肽还原酶的活性以及一氧化氮的产生。讨论了环黄芪醇作为紫外线辐射和过氧化氢暴露诱导淋巴细胞凋亡的调节剂的可能机制。

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来源期刊

Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.