Recent progress towards catalytic asymmetric construction of inherently chiral scaffolds.

IF 39 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Kai Zhu,David R Spring,Bing-Feng Shi,Fengzhi Zhang
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引用次数: 0

Abstract

Inherently chiral scaffolds are a unique type of structurally fascinating building blocks, which have found increasing applications in the field of material chemistry, medicinal chemistry, asymmetric synthesis, molecular recognition and assembly. Owing to the steady demand for these chiral entities, numerous efforts have been made on their enantioselective synthesis. Among the plethora of accomplishments reported, the catalytic asymmetric strategy is emerging as one of the most efficient and sustainable approaches. This protocol provides a powerful platform to achieve enantiomerically pure inherently chiral architectures with structural diversity. In this review article, we aim to generalize the booming and remarkable advancements in asymmetric synthesis of inherently chiral calix[n]arenes, pillar[n]arenes, saddle-shaped scaffolds, mechanically interlocked molecules, and prism-like cages under catalyst control, which would offer valuable insights for future research on the rational design of conceptually novel and streamlined asymmetric synthetic systems, thereby expanding the scope/chemical space and improving the added value of inherently chiral molecules.
催化不对称构建固有手性支架的研究进展。
固有手性支架是一种独特的结构迷人的构建模块,在材料化学、药物化学、不对称合成、分子识别和组装等领域得到了越来越多的应用。由于对这些手性实体的稳定需求,人们对它们的对映选择性合成进行了大量的研究。在报告的众多成就中,催化不对称战略正在成为最有效和可持续的方法之一。该协议为实现具有结构多样性的对映体纯固有手性结构提供了一个强大的平台。本文综述了在催化控制下,固有手性杯[n]芳烃、柱[n]芳烃、鞍形支架、机械互锁分子和棱柱状笼等不对称合成领域取得的重大进展,为今后合理设计概念新颖、流线型的不对称合成体系提供有价值的见解。从而扩大范围/化学空间,提高固有手性分子的附加值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Chemical Society Reviews
Chemical Society Reviews 化学-化学综合
CiteScore
80.80
自引率
1.10%
发文量
345
审稿时长
6.0 months
期刊介绍: Chemical Society Reviews is published by: Royal Society of Chemistry. Focus: Review articles on topics of current interest in chemistry; Predecessors: Quarterly Reviews, Chemical Society (1947–1971); Current title: Since 1971; Impact factor: 60.615 (2021); Themed issues: Occasional themed issues on new and emerging areas of research in the chemical sciences
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