Sex-specific associations of serum 25-hydroxyvitamin D concentrations with incident sarcopenia in older adults: A 2-year follow-up study

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging Pub Date : 2025-10-17 DOI:10.1016/j.jnha.2025.100713

Sihan Song , Joong-Yeon Lim , Miji Kim , Chang Won Won , Hyun-Young Park

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引用次数: 0

Abstract

Objectives

This study aimed to explore the association of circulating vitamin D levels with incidence of sarcopenia and its diagnostic components in older men and women.

Design

Two-year longitudinal study.

Setting

Nationwide Korean Frailty and Aging Cohort Study.

Participants

A total of 1,292 adults (53% women) aged 70–84 years without sarcopenia at baseline and who completed the 2-year follow-up sarcopenia assessment were included.

Measurements

Serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured using a chemiluminescent immunoassay and categorized into sex- and blood collection period-specific quartiles. The appendicular skeletal muscle mass was assessed using dual-energy X-ray absorptiometry. Muscle strength was evaluated using handgrip strength, and physical performance was assessed using the five-times-sit-to-stand test, usual gait speed, and Short Physical Performance Battery. Sarcopenia was defined in accordance with the 2019 consensus of the Asian Working Group for Sarcopenia. Logistic regression and generalized linear models were used to assess the association of serum 25(OH)D concentrations with sarcopenia and its components.

Results

Over the 2-year follow-up, incident sarcopenia occurred in 15.7% of men and 12.1% of women. Serum 25(OH)D concentrations were inversely associated with incident sarcopenia in men (odds ratio [OR] for the highest vs. lowest quartile, 0.47; 95% confidence interval [CI], 0.23–0.94; P for trend = 0.03), whereas no significant association was observed in women. When examining the association between serum 25(OH)D concentrations and components of sarcopenia, the third quartile was associated with lower odds of low muscle mass in men (OR, 0.39; 95% CI, 0.20–0.77) and low physical performance in women (OR, 0.32; 95% CI, 0.15–0.68), compared to the first quartile. Additionally, higher serum 25(OH)D concentrations were associated with more favorable annual changes in usual gait speed in men but not in women.

Conclusion

Low serum 25(OH)D concentrations are associated with a higher likelihood of incident sarcopenia and its components, particularly among men. Adequate 25(OH)D concentrations may help slow age-related decline in muscle mass and function, with potential sex differences.

查看原文本刊更多论文

血清25-羟基维生素D浓度与老年人肌肉减少症的性别特异性关联：一项2年随访研究

目的：本研究旨在探讨循环维生素D水平与老年男性和女性肌肉减少症发病率及其诊断成分的关系。设计：为期两年的纵向研究。背景：韩国全国虚弱和老龄化队列研究。参与者：共有1292名成年人（53%为女性），年龄在70-84岁，基线时无肌少症，并完成了2年随访肌少症评估。测量方法：使用化学发光免疫分析法测量血清25-羟基维生素D [25(OH)D]浓度，并按性别和采血期的特定四分位数进行分类。采用双能x线骨密度仪评估阑尾骨骼肌质量。肌肉力量通过握力来评估，身体表现通过五次坐立测试、通常的步态速度和短物理性能电池来评估。肌少症的定义是根据2019年亚洲肌少症工作组的共识。采用Logistic回归和广义线性模型评估血清25(OH)D浓度与肌肉减少症及其组成部分的关系。结果：在2年的随访中，15.7%的男性和12.1%的女性发生了肌肉减少症。血清25(OH)D浓度与男性发生的肌肉减少症呈负相关（最高四分位数vs最低四分位数的比值比为0.47；95%可信区间[CI]为0.23-0.94；趋势P = 0.03），而在女性中未观察到显著相关性。当检查血清25(OH)D浓度与肌肉减少症成分之间的关系时，与第一个四分位数相比，第三个四分位数与男性低肌肉质量（OR, 0.39; 95% CI, 0.20-0.77）和女性低体力表现（OR, 0.32; 95% CI, 0.15-0.68）的几率较低相关。此外，较高的血清25(OH)D浓度与男性通常步态速度的年度变化更有利相关，而与女性无关。结论：血清25(OH)D浓度低与肌肉减少症及其组成部分发生的可能性较高有关，尤其是在男性中。充足的25(OH)D浓度可能有助于减缓与年龄相关的肌肉质量和功能下降，但存在潜在的性别差异。

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来源期刊

Journal of Nutrition Health & Aging 医学-老年医学

CiteScore

7.80

自引率

3.40%

发文量

136

审稿时长

4-8 weeks

期刊介绍： There is increasing scientific and clinical interest in the interactions of nutrition and health as part of the aging process. This interest is due to the important role that nutrition plays throughout the life span. This role affects the growth and development of the body during childhood, affects the risk of acute and chronic diseases, the maintenance of physiological processes and the biological process of aging. A major aim of "The Journal of Nutrition, Health & Aging" is to contribute to the improvement of knowledge regarding the relationships between nutrition and the aging process from birth to old age.