Association between cMIND diet adherence and frailty among Chinese older adults: A 10-year longitudinal study

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging Pub Date : 2025-10-17 DOI:10.1016/j.jnha.2025.100709

Lin Yang , Mengying Li , Jing Shu , Lizheng Cao

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引用次数: 0

Abstract

Background

Both cognitive impairment and diet are significant factors associated with frailty, however, the association between the Chinese Mediterranean-DASH Intervention for Neurodegenerative Delay (cMIND) diet and frailty remains unclear.

Methods

This longitudinal study analyzed data from 1,943 adults aged ≥65 in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) spanning 2008–2018. Adherence to the cMIND diet was assessed using a food frequency questionnaire, whereas frailty status was determined using the frailty index. The cMIND dietary scores were categorized into three groups based on tertiles: (T1:0−4; T2:4.5–5.5; T3:6–12). The association between cMIND adherence and frailty incidence was assessed using Cox proportional hazards models, while the dose-response relationship was examined with restricted cubic splines (with knots at the 5th, 35th, 65th, and 95th percentiles).

Results

The mean age was 74.9 ± 7.3 years; 50.5% were female. The restricted cubic spline model revealed a significant nonlinear association between baseline cMIND dietary scores and frailty risk (nonlinear p < 0.05). Subsequently, the Cox proportional hazards model showed that, after adjusting for covariates, participants in the highest tertile of cMIND scores exhibited a 16% reduction in frailty risk compared to those in the lowest tertile (HR = 0.84, 95% CI: 0.72−0.97, p = 0.022). However, subgroup analyses revealed that the association varied according to baseline cognitive function. A significant inverse association was present in those with normal cognition (HR = 0.91, 95% CI: 0.86−0.96) but absent in those with cognitive impairment (HR = 1.01, 95% CI: 0.93–1.09; interaction p = 0.037).

Conclusion

Higher adherence to the cMIND diet is associated with a lower risk of frailty among older adults in China, specifically in those with normal cognitive function at baseline.

查看原文本刊更多论文

中国老年人坚持cMIND饮食与身体虚弱之间的关系：一项为期10年的纵向研究。

背景：认知障碍和饮食都是与虚弱相关的重要因素，然而，中国地中海- dash干预神经退行性延迟（cMIND）饮食与虚弱之间的关系尚不清楚。方法：本纵向研究分析了2008-2018年中国纵向健康寿命调查（CLHLS）中1,943名年龄≥65岁的成年人的数据。使用食物频率问卷评估cMIND饮食的依从性，而使用虚弱指数确定虚弱状态。cMIND膳食评分按位数分为3组：（T1:0-4; T2:4.5-5.5; T3:6-12）。使用Cox比例风险模型评估cMIND依从性与虚弱发生率之间的关系，同时使用受限三次样条（在第5、35、65和95百分位处有结）检查剂量-反应关系。结果：患者平均年龄74.9±7.3岁；50.5%为女性。限制三次样条模型显示基线cMIND饮食评分与虚弱风险之间存在显著的非线性关联（非线性p < 0.05）。随后，Cox比例风险模型显示，在调整协变量后，cMIND得分最高分位数的参与者比得分最低分位数的参与者表现出16%的衰弱风险降低（HR = 0.84, 95% CI: 0.72-0.97, p = 0.022）。然而，亚组分析显示，这种关联根据基线认知功能而变化。认知正常组存在显著负相关（HR = 0.91, 95% CI: 0.86-0.96），而认知障碍组无显著负相关（HR = 1.01, 95% CI: 0.93-1.09；交互作用p = 0.037）。结论：在中国老年人中，较高的cMIND饮食依从性与较低的衰弱风险相关，特别是在基线认知功能正常的老年人中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nutrition Health & Aging 医学-老年医学

CiteScore

7.80

自引率

3.40%

发文量

136

审稿时长

4-8 weeks

期刊介绍： There is increasing scientific and clinical interest in the interactions of nutrition and health as part of the aging process. This interest is due to the important role that nutrition plays throughout the life span. This role affects the growth and development of the body during childhood, affects the risk of acute and chronic diseases, the maintenance of physiological processes and the biological process of aging. A major aim of "The Journal of Nutrition, Health & Aging" is to contribute to the improvement of knowledge regarding the relationships between nutrition and the aging process from birth to old age.