Association between cardiovascular health assessed by Life’s Essential 8 and diabetic retinopathy: The mediating role of phenotypic age and biological age

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging Pub Date : 2025-10-21 DOI:10.1016/j.jnha.2025.100711

Jia Wang , Mingrui Jin , Zhenkang Qiu , Mao Li , Jing Ma

{"title":"Association between cardiovascular health assessed by Life’s Essential 8 and diabetic retinopathy: The mediating role of phenotypic age and biological age","authors":"Jia Wang , Mingrui Jin , Zhenkang Qiu , Mao Li , Jing Ma","doi":"10.1016/j.jnha.2025.100711","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>The American Heart Association (AHA) recently updated the Life's Essential 8 (LE8) metrics to measure ideal cardiovascular health (CVH). Diabetic retinopathy (DR) is the leading cause of vision impairment, exhibiting a rising prevalence globally. However, the association between LE8 and DR, as well as the mediating role of phenotypic age (PA) and biological age (BA), is still unclear.</div></div><div><h3>Methods</h3><div>LE8 scores were categorized into three groups: low (0–49), moderate (50–74), and high (75–100). PA and BA were computed using validated algorithms incorporating clinical biomarkers. Weighted logistic regression and linear analysis were employed to assess the relationship between LE8 and DR. The mediation analysis was conducted to explore the mediating role of PA and BA.</div></div><div><h3>Results</h3><div>Our study included 1129 participants with non-DR and 329 participants with DR from the National Health and Nutrition Examination Survey (NHANES). Higher LE8 scores were inversely associated with DR prevalence after adjusting for all covariates (OR = 0.24; 95% CI: 0.11–0.50; <em>P</em> for trend < 0.001). Each 10-point LE8 increase was related to a 23% decrease of DR (OR = 0.77, 95% CI: 0.69–0.84). Mediation analysis indicated that PA and BA partially mediated 35.61% and 46.38% of the association between LE8 and DR, respectively.</div></div><div><h3>Conclusions</h3><div>The LE8 scores were negatively associated with the incidence of DR, while PA and BA partially mediated the association between LE8 scores and DR.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"100711"},"PeriodicalIF":4.0000,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nutrition Health & Aging","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1279770725002362","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

The American Heart Association (AHA) recently updated the Life's Essential 8 (LE8) metrics to measure ideal cardiovascular health (CVH). Diabetic retinopathy (DR) is the leading cause of vision impairment, exhibiting a rising prevalence globally. However, the association between LE8 and DR, as well as the mediating role of phenotypic age (PA) and biological age (BA), is still unclear.

Methods

LE8 scores were categorized into three groups: low (0–49), moderate (50–74), and high (75–100). PA and BA were computed using validated algorithms incorporating clinical biomarkers. Weighted logistic regression and linear analysis were employed to assess the relationship between LE8 and DR. The mediation analysis was conducted to explore the mediating role of PA and BA.

Results

Our study included 1129 participants with non-DR and 329 participants with DR from the National Health and Nutrition Examination Survey (NHANES). Higher LE8 scores were inversely associated with DR prevalence after adjusting for all covariates (OR = 0.24; 95% CI: 0.11–0.50; P for trend < 0.001). Each 10-point LE8 increase was related to a 23% decrease of DR (OR = 0.77, 95% CI: 0.69–0.84). Mediation analysis indicated that PA and BA partially mediated 35.61% and 46.38% of the association between LE8 and DR, respectively.

Conclusions

The LE8 scores were negatively associated with the incidence of DR, while PA and BA partially mediated the association between LE8 scores and DR.

查看原文本刊更多论文

Life's Essential 8评估的心血管健康与糖尿病视网膜病变之间的关系：表型年龄和生物学年龄的中介作用

背景：美国心脏协会（AHA）最近更新了衡量理想心血管健康（CVH）的生命基本8 （LE8）指标。糖尿病性视网膜病变（DR）是视力损害的主要原因，全球患病率呈上升趋势。然而，LE8与DR之间的关系以及表型年龄（PA）和生物学年龄（BA）的中介作用尚不清楚。方法：将LE8评分分为低（0 ~ 49）、中（50 ~ 74）、高（75 ~ 100）3组。PA和BA采用结合临床生物标志物的验证算法计算。采用加权logistic回归和线性分析来评估LE8与dr之间的关系，并进行中介分析来探讨PA和BA的中介作用。结果：我们的研究纳入了来自国家健康与营养检查调查（NHANES）的1129名非DR和329名DR参与者。调整所有协变量后，较高的LE8评分与DR患病率呈负相关（OR = 0.24; 95% CI: 0.11-0.50; P < 0.001）。LE8每增加10点，DR降低23% （OR = 0.77, 95% CI: 0.69-0.84）。中介分析表明，PA和BA分别部分介导了LE8和DR之间的关联，分别为35.61%和46.38%。结论：LE8评分与DR发生率呈负相关，PA和BA在LE8评分与DR之间起部分中介作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Nutrition Health & Aging 医学-老年医学

CiteScore

7.80

自引率

3.40%

发文量

136

审稿时长

4-8 weeks

期刊介绍： There is increasing scientific and clinical interest in the interactions of nutrition and health as part of the aging process. This interest is due to the important role that nutrition plays throughout the life span. This role affects the growth and development of the body during childhood, affects the risk of acute and chronic diseases, the maintenance of physiological processes and the biological process of aging. A major aim of "The Journal of Nutrition, Health & Aging" is to contribute to the improvement of knowledge regarding the relationships between nutrition and the aging process from birth to old age.