Muhammad Abdullah, Shih-Hsien Lin, Li-Chung Huang, Nan-Tsing Chiu, Shih-Ming Huang, Yen Kuang Yang
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引用次数: 0
Abstract
Background: Cognitive deficits in various psychiatric disorders could be linked to attenuated striatal dopaminergic tone and disrupted striatocortical functional connectivity (FC). Hyperthyroidism's associated decrease in striatal dopaminergic tone and its effects on striatocortical FC may also be the underlying cause of cognitive deficits in Graves' disease (GD). This study investigated striatal dopamine transporter (DAT) availability, its effect on striatal seed-based (six seeds) whole-brain FC and IQ as an index of global cognitive function in GD.
Methods: We recruited 34 GD patients and 24 healthy controls (HCs). DAT availability by single-photon emission tomography, FC by resting-state functional MRI, and Full-scale IQ (FIQ) were measured.
Results: Left striatal DAT availability was significantly lower and strongly associated with FC between left ventral rostral putamen (VRP)-left insula, left VRP-left supramarginal gyrus, and left dorsal caudate (DC)-left superior parietal gyrus in the GD patients as compared with the HCs. Right striatal DAT availability was also significantly lower and strongly associated with FC between the right VRP-left insula. FIQ was significantly lower and weakly associated with FC between right dorsal caudal putamen (DCP)-left temporal pole, left DCP-left middle frontal gyrus, and left DCP-left superior parietal gyrus.
Conclusions: Cognitive deficits in GD could be the result of dysfunction in the striatal dopaminergic system and altered striatocortical FC. Notably, the FC between the parietal gyrus (an area known to be associated with IQ) and striatum exhibited deviated associations with DAT availability and FIQ scores, suggesting the role of dopamine-associated disrupted parieto-striatal connectivity in compromising IQ.
期刊介绍：
Journal of the Formosan Medical Association (JFMA), published continuously since 1902, is an open access international general medical journal of the Formosan Medical Association based in Taipei, Taiwan. It is indexed in Current Contents/ Clinical Medicine, Medline, ciSearch, CAB Abstracts, Embase, SIIC Data Bases, Research Alert, BIOSIS, Biological Abstracts, Scopus and ScienceDirect.
As a general medical journal, research related to clinical practice and research in all fields of medicine and related disciplines are considered for publication. Article types considered include perspectives, reviews, original papers, case reports, brief communications, correspondence and letters to the editor.
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