Clinical and Ethical Considerations in Nanotechnology-Based Dermatologic Care.

Abstract

Nanodermatology is the application of nanotechnology specifically to dermatology. We discuss the pros and cons of translating these innovations into routine dermatology practice, as well as the unique safety challenges, regulatory issues, and ethical and equity concerns surrounding nanodermatology. Unlike other emerging technologies, nanodermatology involves transcutaneous exposure to engineered nanoparticles that may penetrate beyond the epidermis, persist in tissues, and accumulate systemically. These characteristics create distinct safety and ethical challenges, including invisible patient exposure, uncertain long-term toxicologic effects, and unequal regulatory oversight across countries. The specific ethical issues involve nonmaleficence, informed consent, privacy, autonomy, and justice. Nanotechnology is emerging as a pivotal frontier in dermatology, with applications ranging from targeted drug delivery to nanoscale diagnostic sensors and advanced cosmetic formulations.¹ Examples include nanoparticle-based topical formulations that increase delivery of immunomodulators into psoriatic plaques, micelle carriers for enhanced stratum corneum penetration of tacrolimus, and nanosensors capable of detecting inflammatory biomarkers in real-time.² Recent studies emphasize nanodermatology, the application of nanotechnology specifically to dermatology as a potential solution for persistent challenges such as improving therapeutic efficacy, reducing systemic toxicity, and enabling precision dermatologic interventions.³ Translating these innovations into routine practice raises critical ethical, safety, and equity concerns.