Benzo[d][1,3]Oxazine‐Assisted C─H Annulation of Arenes with Diarylacetylenes: Access to 3,4‐diarylisoquinolinones

IF 2.7 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-10-01 DOI:10.1002/ajoc.202500225

P. Naveen Reddy , Kiran Aswale , Rajashaker Bantu , B. Sridhar , B. V. Subba Reddy

引用次数: 0

Abstract

A novel Rh(III)‐catalyzed [4 + 2] annulation of diarylacetylenes with 2‐aryl‐4H‐benzo[d][1,3]oxazines is described to produce a new class of 3,4‐diarylisoquinolinones through a ring‐opening C─H annulation of benzo[d][1,3]oxazine moiety. This is the first report on C─H functionalazation of 2‐aryl‐4H‐benzo[d][1,3]oxazines with diarylalkynes for the synthesis of 3,4‐diarylisoquinolinone scaffolds. The scope of this method is well exemplified with diverse substrates bearing different functional groups including electron‐rich and electron‐deficient substituents.

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苯并[d][1,3]恶嗪辅助芳烃与二芳基乙炔的C─H环接：制备3,4-二芳基异喹啉酮

介绍了一种新的Rh（III）催化的二芳基乙炔与2-芳基- 4h -苯并[d][1,3]恶嗪的[4 + 2]环化反应，通过苯并[d][1,3]恶嗪部分的开环C─H环化反应，生成了一类新的3,4-二芳基异喹啉酮。本文首次报道了2-芳基- 4h -苯并[d][1,3]恶嗪与二芳炔的C─H功能化合成3,4-二芳基异喹啉酮支架。这种方法的范围很好地例证了具有不同官能团的不同底物，包括富电子和缺电子取代基。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.