Exosomes in Intervertebral Disc Regeneration: Roles, Opportunities, and Challenges

IF 4.4 Q2 ENGINEERING, BIOMEDICAL

Advanced Nanobiomed Research Pub Date : 2025-06-21 DOI:10.1002/anbr.202500074

Xianglong Zhou, Tianyi Xia, Jiheng Xiao, Jianhui Xiang, Hanhong Fang, Haoran Zhou, Yiqiang Hu, Liming Xiong

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引用次数: 0

Abstract

Intervertebral disc degeneration (IVDD), a major cause of low back pain, poses significant global health and socioeconomic challenges. Current therapies have limited effectiveness in reversing degeneration, which underscores the need for advanced treatment strategies. Exosomes, which are nanoscale extracellular vesicles, have emerged as promising therapeutic agents for IVDD due to their unique biological properties. They exert their effects through multiple mechanisms, such as regulating the extracellular matrix, promoting cell proliferation, and exerting anti-inflammatory effects. This review summarizes recent advances in exosome-based therapies for IVDD. It encompasses their mechanisms, cell sources, engineering technologies, and progress in clinical translation. Additionally, the challenges and opportunities related to their future clinical application are discussed, and their potential to revolutionize the treatment of IVDD is highlighted.

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外泌体在椎间盘再生中的作用、机遇和挑战

椎间盘退变（IVDD）是腰痛的一个主要原因，对全球健康和社会经济构成重大挑战。目前的治疗方法在逆转退行性变方面效果有限，这强调了需要先进的治疗策略。外泌体是一种纳米级的细胞外囊泡，由于其独特的生物学特性，已成为治疗IVDD的有希望的药物。它们通过调节细胞外基质、促进细胞增殖、发挥抗炎作用等多种机制发挥作用。本文综述了体外泌体治疗IVDD的最新进展。它包括它们的机制、细胞来源、工程技术和临床翻译的进展。此外，讨论了与它们未来临床应用相关的挑战和机遇，并强调了它们革新IVDD治疗的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Nanobiomed Research nanomedicine, bioengineering and biomaterials-

CiteScore

5.00

自引率

5.90%

发文量

审稿时长

21 weeks

期刊介绍： Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science. The scope of Advanced NanoBiomed Research will cover the following key subject areas: ▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging. ▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications. ▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture. ▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs. ▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization. ▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems. with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.