Magnetic Multifunctional Nanoparticles for Effective Targeted Cancer Therapy

IF 4.4 Q2 ENGINEERING, BIOMEDICAL

Advanced Nanobiomed Research Pub Date : 2025-06-04 DOI:10.1002/anbr.202400176

Yao Miao, Qing Bao, Tao Yang, Mingying Yang, Chuanbin Mao

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Abstract

Due to the lack of targeting specificity, rapid clearance, and high toxicity associated with small molecule drugs in tumor treatment, the design of an effective drug delivery system is crucial. To better overcome physiological barriers and achieve prolonged tumor retention, nanoparticles (Fe₃O₄@SiO₂@Au, termed FSA-NPs), made of core–shell NPs (Fe₃O₄@SiO₂), consisting of a Fe₃O₄ core and a mesoporous silica (SiO₂) shell, and with their surfaces decorated with gold NPs, are constructed. The FSA-NPs have a size range of 60–80 nm and a mildly negative surface charge. The magnetic Fe₃O₄ core imparts magnetic targeting capabilities to FSA-NPs, while the high porosity of the mesoporous silica shell enables efficient drug loading. Additionally, the gold NPs can convert light into heat. As a result, after being internalized by A549 lung cancer cells, FSA-NPs exhibit potent cytotoxic effects against the cancer cells under an applied magnetic field, making them a promising theranostic agent for integrated cancer diagnosis and therapy.

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磁性多功能纳米颗粒有效靶向治疗癌症

由于小分子药物在肿瘤治疗中缺乏靶向特异性、快速清除率和高毒性，设计有效的给药系统至关重要。为了更好地克服生理障碍并延长肿瘤滞留时间，纳米颗粒（Fe3O4@SiO2@Au，称为FSA-NPs）由核-壳NPs （Fe3O4@SiO2）制成，由Fe3O4核和介孔二氧化硅（SiO2）壳组成，表面装饰有金NPs。FSA-NPs的尺寸范围为60-80 nm，表面带轻微的负电荷。磁性Fe3O4核赋予了FSA-NPs磁性靶向能力，而介孔二氧化硅壳的高孔隙率使其能够高效装载药物。此外，金纳米粒子可以将光转化为热。因此，FSA-NPs被A549肺癌细胞内化后，在外加磁场作用下对癌细胞表现出强大的细胞毒作用，是一种很有前景的癌症综合诊断和治疗药物。

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来源期刊

Advanced Nanobiomed Research nanomedicine, bioengineering and biomaterials-

CiteScore

5.00

自引率

5.90%

发文量

审稿时长

21 weeks

期刊介绍： Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science. The scope of Advanced NanoBiomed Research will cover the following key subject areas: ▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging. ▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications. ▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture. ▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs. ▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization. ▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems. with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.